{"doi":"10.1136/rmdopen-2024-004492","title":"Autoantibodies, cutaneous subset and immunosuppressants contribute to the cancer risk in systemic sclerosis","abstract":"<jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>Systemic sclerosis (SSc) is associated with an increased risk of cancer. We aimed to assess the prevalence of cancer in our cohort and to explore possible associations with clinical, immunological and treatment characteristics.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Our retrospective monocentric cohort study of patients with SSc recorded prevalent and incident cases of malignancy, including those diagnosed within 3 years of the SSc onset (defined as cancer-associated scleroderma) and sought associations with the clinical characteristics and the serum autoantibody profiling performed using RNA and protein immunoprecipitation, Western-blot, immunoblot and ELISA at the time of SSc diagnosis, prior to any specific treatment.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Among 290 patients with SSc, the overall prevalence of cancer was 20%, with 8% of cases being cancer-associated scleroderma. Both conditions were more frequent in elderly patients and in patients with positive anti-Ro52 or anti-U3-RNP. Cancer-associated scleroderma was significantly more prevalent among patients negative for both anti-centromere (ACA) and anti-topoisomerase-1 (TOPO1) antibodies, especially in the case of diffuse SSc. Immunosuppressants were not significantly associated with cancer. Patients triple negative for ACA, TOPO1 and anti-RNA polymerase III antibodies had a significantly higher risk of breast cancer.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Cancer surveillance should be particularly careful in patients with diffuse SSc, increased age at disease onset and without classical SSc-related autoantibodies.</jats:p>\n               </jats:sec>","journal":"RMD Open","year":2024,"id":613299,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":644215,"name":"Francesca Motta","orcid":"0000-0002-8093-2734","position":1,"is_corresponding":false},{"id":1579929,"name":"Natasa Isailovic","orcid":"0000-0002-9819-8822","position":2,"is_corresponding":false},{"id":1579930,"name":"Angela Ceribelli","orcid":null,"position":3,"is_corresponding":false},{"id":1579931,"name":"Rita Ragusa","orcid":null,"position":4,"is_corresponding":false},{"id":1579932,"name":"Emanuele Nappi","orcid":null,"position":5,"is_corresponding":false},{"id":1421241,"name":"Stefanos Bonovas","orcid":"0000-0001-6102-6579","position":6,"is_corresponding":false},{"id":622862,"name":"Carlo Selmi","orcid":"0000-0002-0323-0376","position":7,"is_corresponding":false},{"id":652198,"name":"Maria De Santis","orcid":"0000-0002-3196-1336","position":8,"is_corresponding":false},{"id":1579928,"name":"Antonio Tonutti","orcid":"0009-0000-9534-6853","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Autoantibodies, cutaneous subset and immunosuppressants contribute to the cancer risk in systemic sclerosis","abstract":"<jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>Systemic sclerosis (SSc) is associated with an increased risk of cancer. We aimed to assess the prevalence of cancer in our cohort and to explore possible associations with clinical, immunological and treatment characteristics.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Our retrospective monocentric cohort study of patients with SSc recorded prevalent and incident cases of malignancy, including those diagnosed within 3 years of the SSc onset (defined as cancer-associated scleroderma) and sought associations with the clinical characteristics and the serum autoantibody profiling performed using RNA and protein immunoprecipitation, Western-blot, immunoblot and ELISA at the time of SSc diagnosis, prior to any specific treatment.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Among 290 patients with SSc, the overall prevalence of cancer was 20%, with 8% of cases being cancer-associated scleroderma. Both conditions were more frequent in elderly patients and in patients with positive anti-Ro52 or anti-U3-RNP. Cancer-associated scleroderma was significantly more prevalent among patients negative for both anti-centromere (ACA) and anti-topoisomerase-1 (TOPO1) antibodies, especially in the case of diffuse SSc. Immunosuppressants were not significantly associated with cancer. Patients triple negative for ACA, TOPO1 and anti-RNA polymerase III antibodies had a significantly higher risk of breast cancer.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Cancer surveillance should be particularly careful in patients with diffuse SSc, increased age at disease onset and without classical SSc-related autoantibodies.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39306344","pmcid":"PMC11418480","openalex_id":"https://openalex.org/W4402695874","authors":[],"funders":[{"funder_name":"Italian Ministry of Health","grant_id":"N/A","title":null}],"total_grants":1,"fwci":2.7249,"citation_percentile":0.90756071,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://rmdopen.bmj.com/content/10/3/e004492.full.pdf","host_type":"journal"},{"url":"https://rmdopen.bmj.com/content/10/3/e004492.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1136/rmdopen-2024-004492","host_type":"publisher"},{"url":"https://doi.org/10.1136/rmdopen-2024-004492","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39306344","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11418480","host_type":"repository"},{"url":"https://doaj.org/article/6ebc8d8768d04041b9fac8a561e4652e","host_type":"repository"},{"url":"https://doi.org/10.5281/zenodo.15020236","host_type":"repository"},{"url":"https://doi.org/10.5281/zenodo.15020237","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11418480/pdf/rmdopen-10-3.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11418480","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11418480?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Systemic Sclerosis and Related Diseases","Inflammatory Myopathies and Dermatomyositis","Skin Diseases and Diabetes"],"mesh_terms":["Adult","Aged","Autoantibodies","DNA Topoisomerases, Type I","Female","Humans","Immunosuppression Therapy","Immunosuppressive Agents","Male","Middle Aged","Mycophenolic Acid","Neoplasms","Retrospective Studies","Risk Factors","Scleroderma, Systemic","Prevalence"],"keywords":["Medicine","Autoantibody","Cancer","Malignancy","Cohort","Internal medicine","Scleroderma (fungus)","Breast cancer","Antibody","Oncology","Immunology","Prevalence","Autoimmunity","risk factors","Connective Tissue Diseases","Scleroderma, Systemic"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.5281/zenodo.15020237","title":"Dataset \"Autoantibodies, cutaneous subset and immunosuppressants contribute to the cancer risk in systemic sclerosis\"","publisher":"Zenodo","resource_type":"Dataset"},{"doi":"10.5281/zenodo.15020236","title":"Dataset \"Autoantibodies, cutaneous subset and immunosuppressants contribute to the cancer risk in systemic sclerosis\"","publisher":"Zenodo","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T07:31:40.155441Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}