{"doi":"10.1136/jnnp-2022-329680","title":"Brain age gap in neuromyelitis optica spectrum disorders and multiple sclerosis","abstract":"OBJECTIVE: To evaluate the clinical significance of deep learning-derived brain age prediction in neuromyelitis optica spectrum disorder (NMOSD) relative to relapsing-remitting multiple sclerosis (RRMS). METHODS: This cohort study used data retrospectively collected from 6 tertiary neurological centres in China between 2009 and 2018. In total, 199 patients with NMOSD and 200 patients with RRMS were studied alongside 269 healthy controls. Clinical follow-up was available in 85 patients with NMOSD and 124 patients with RRMS (mean duration NMOSD=5.8±1.9 (1.9-9.9) years, RRMS=5.2±1.7 (1.5-9.2) years). Deep learning was used to learn 'brain age' from MRI scans in the healthy controls and estimate the brain age gap (BAG) in patients. RESULTS: A significantly higher BAG was found in the NMOSD (5.4±8.2 years) and RRMS (13.0±14.7 years) groups compared with healthy controls. A higher baseline disability score and advanced brain volume loss were associated with increased BAG in both patient groups. A longer disease duration was associated with increased BAG in RRMS. BAG significantly predicted Expanded Disability Status Scale worsening in patients with NMOSD and RRMS. CONCLUSIONS: There is a clear BAG in NMOSD, although smaller than in RRMS. The BAG is a clinically relevant MRI marker in NMOSD and RRMS.","journal":"Journal of Neurology Neurosurgery & Psychiatry","year":2022,"id":257962,"datarank":0.5953660593779757,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.15370021250300958,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.15370021250300958,"corpus_percentile":66.8832675794848,"corpus_rank":4282,"citation_count":18,"citer_count":11,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7755,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":908889,"name":"Xiaolu Xu","orcid":"0000-0001-9963-529X","position":1,"is_corresponding":false},{"id":908890,"name":"Yunyun Duan","orcid":"0000-0002-8753-0260","position":2,"is_corresponding":false},{"id":909595,"name":"Ningnannan Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":908891,"name":"Jie Sun","orcid":"0000-0001-5611-1672","position":4,"is_corresponding":false},{"id":908892,"name":"Haiqing Li","orcid":"0000-0003-4075-9356","position":5,"is_corresponding":false},{"id":828688,"name":"Yuxin Li","orcid":"0000-0003-2107-6744","position":6,"is_corresponding":false},{"id":908893,"name":"Yongmei Li","orcid":"0009-0005-1892-0862","position":7,"is_corresponding":false},{"id":908894,"name":"Chun Zeng","orcid":"0000-0001-8670-1630","position":8,"is_corresponding":false},{"id":908895,"name":"Xuemei Han","orcid":"0000-0002-4423-2079","position":9,"is_corresponding":false},{"id":741877,"name":"Fuqing Zhou","orcid":"0000-0002-0890-910X","position":10,"is_corresponding":false},{"id":909596,"name":"Muhua Huang","orcid":null,"position":11,"is_corresponding":false},{"id":908896,"name":"Runzhi Li","orcid":"0000-0003-0117-4195","position":12,"is_corresponding":false},{"id":908897,"name":"Zhizheng Zhuo","orcid":"0000-0002-6635-8705","position":13,"is_corresponding":false},{"id":242544,"name":"Frederik Barkhof","orcid":"0000-0003-3543-3706","position":14,"is_corresponding":false},{"id":54146,"name":"James H. Cole","orcid":"0000-0003-1908-5588","position":15,"is_corresponding":false},{"id":628022,"name":"Yaou Liu","orcid":"0000-0002-9930-0331","position":16,"is_corresponding":false},{"id":908888,"name":"Wei Ren","orcid":"0000-0003-1862-413X","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T00:25:38.634785Z","pmid":"36216455","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}