{"doi":"10.1136/jitc-2023-007927","title":"Metastatic gastric cancer target lesion complete response with Claudin18.2-CAR T cells","abstract":"Treatment of hematologic malignancies with patient-derived anti-CD19 chimeric antigen receptor (CAR) T-cells has demonstrated long-term remissions for patients with otherwise treatment-refractory advanced leukemia and lymphoma. Conversely, CAR T-cell treatment of solid tumors, including advanced gastric cancer (GC), has proven more challenging due to on-target off-tumor toxicities, poor tumor T-cell infiltration, inefficient CAR T-cell expansion, immunosuppressive tumor microenvironments, and demanding preconditioning regimens. We report the exceptional results of autologous Claudin18.2-targeted CAR T cells (CT041) in a patient with metastatic GC, who had progressed on four lines of combined systemic chemotherapy and immunotherapy. After two CT041 infusions, the patient had target lesion complete response and sustained an 8-month overall partial response with only minimal ascites. Moreover, tumor-informed circulating tumor DNA (ctDNA) reductions coincided with rapid CAR T-cell expansion and radiologic response. No severe toxicities occurred, and the patient’s quality of life significantly improved. This experience supports targeting Claudin18.2-positive GC with CAR T-cell therapy and helps to validate ctDNA as a biomarker in CAR T-cell therapy. Clinical Insight: Claudin18.2-targeted CAR T cells can safely provide complete objective and ctDNA response in salvage metastatic GC.","journal":"Journal for ImmunoTherapy of Cancer","year":2024,"id":420575,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":505233,"name":"Joseph Chao","orcid":"0000-0002-1809-504X","position":1,"is_corresponding":false},{"id":9510,"name":"H. Ma","orcid":"0000-0002-8916-6220","position":2,"is_corresponding":false},{"id":436418,"name":"Michael G. Hahn","orcid":"0000-0003-2136-5191","position":3,"is_corresponding":false},{"id":1010750,"name":"Gloria Sierra","orcid":"0000-0001-8398-7477","position":4,"is_corresponding":false},{"id":1212024,"name":"Jie Jia","orcid":"0000-0002-9583-1055","position":5,"is_corresponding":false},{"id":1212025,"name":"Amanda Y Hendrix","orcid":"0000-0002-2259-9275","position":6,"is_corresponding":false},{"id":655147,"name":"Joy Nolte Fong","orcid":"0000-0003-0848-0101","position":7,"is_corresponding":false},{"id":1212706,"name":"Audrey Ween","orcid":null,"position":8,"is_corresponding":false},{"id":1193863,"name":"Peter Vu","orcid":"0000-0002-1544-0637","position":9,"is_corresponding":false},{"id":360652,"name":"Aaron Miller","orcid":"0000-0001-8324-7356","position":10,"is_corresponding":false},{"id":273362,"name":"Michael Y. Choi","orcid":"0000-0002-9107-2186","position":11,"is_corresponding":false},{"id":1212026,"name":"Benjamin Heyman","orcid":"0000-0001-6707-0861","position":12,"is_corresponding":false},{"id":1096001,"name":"Gregory A. Daniels","orcid":"0000-0001-9087-8009","position":13,"is_corresponding":false},{"id":232661,"name":"Dan S. Kaufman","orcid":"0000-0002-2003-2494","position":14,"is_corresponding":false},{"id":477605,"name":"Catriona Jamieson","orcid":"0000-0001-8057-6613","position":15,"is_corresponding":false},{"id":1212027,"name":"Zonghai Li","orcid":"0000-0003-2448-3636","position":16,"is_corresponding":false},{"id":510055,"name":"Ezra E.W. Cohen","orcid":"0000-0002-9872-6242","position":17,"is_corresponding":false},{"id":642058,"name":"Gregory P. Botta","orcid":"0000-0001-9606-4508","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T01:57:31.041511Z","pmid":"38316518","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}