{"doi":"10.1136/jitc-2022-004902","title":"Imaging cellular immunotherapies and immune cell biomarkers: from preclinical studies to patients","abstract":"Cellular immunotherapies have emerged as a successful therapeutic approach to fight a wide range of human diseases, including cancer. However, responses are limited to few patients and tumor types. An in-depth understanding of the complexity and dynamics of cellular immunotherapeutics, including what is behind their success and failure in a patient, the role of other immune cell types and molecular biomarkers in determining a response, is now paramount. As the cellular immunotherapy arsenal expands, whole-body non-invasive molecular imaging can shed a light on their in vivo fate and contribute to the reliable assessment of treatment outcome and prediction of therapeutic response. In this review, we outline the non-invasive strategies that can be tailored toward the molecular imaging of cellular immunotherapies and immune-related components, with a focus on those that have been extensively tested preclinically and are currently under clinical development or have already entered the clinical trial phase. We also provide a critical appraisal on the current role and consolidation of molecular imaging into clinical practice.","journal":"Journal for ImmunoTherapy of Cancer","year":2022,"id":249527,"datarank":0.9416950959361765,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.4366007214382052,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.4366007214382052,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":24,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227919,"name":"Prasad S. Adusumilli","orcid":"0000-0002-1699-2046","position":1,"is_corresponding":false},{"id":255787,"name":"Heiko Schöder","orcid":"0000-0002-5170-4185","position":2,"is_corresponding":false},{"id":218304,"name":"Vladimir Ponomarev","orcid":"0000-0002-9119-9128","position":3,"is_corresponding":false},{"id":697123,"name":"Alessia Volpe","orcid":"0000-0003-3087-9178","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:24:23.754337Z","pmid":"36137649","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}