{"doi":"10.1136/jcp.52.7.504","title":"Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability.","abstract":"<jats:p>AIM: To investigate the role of DNA microsatellite instability (MSI) in gastric carcinogenesis by studying associations between MSI status, clinicopathological features, and loss of genetic loci. METHODS: Six microsatellite loci and loss of heterozygosity at APC, DCC, and MCC were analysed by polymerase chain reaction based methods in 53 cases of advanced gastric cancer. RESULTS: MSI was observed in 32.1% of gastric carcinomas (17/53) and 20% of foci of intestinal metaplasia (3/15). Seven gastric carcinomas (13.7%) were MSI-high (MSI-H) (three loci or more) and 10 (18.9%) were MSI-low (MSI-L) (one or two loci). The frequency of MSI-H was higher in intestinal (25.0%) than in diffuse carcinomas (3.7%) (p &lt; 0.05). None of the MSI-H tumours showed loss of heterozygosity at APC, MCC, or DCC loci. CONCLUSIONS: MSI may have an important and early role in a subset of gastric cancers, particularly the intestinal type. The MSI-H subset of gastric cancer has features in common with its colorectal counterpart, whereas MSI-L and microsatellite stable cancers appear to develop through the loss of heterozygosity pathway.</jats:p>","journal":"Journal of Clinical Pathology","year":1999,"id":611991,"datarank":2.129578107516754,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":1.5800438605973068,"self_endowment_contribution":0.5495342469194471,"citer_contribution":1.5800438605973068,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":38,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1575483,"name":"J R Jass","orcid":null,"position":1,"is_corresponding":false},{"id":1575484,"name":"D X Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1575485,"name":"X D Zhou","orcid":null,"position":3,"is_corresponding":false},{"id":1575486,"name":"Y H Luo","orcid":null,"position":4,"is_corresponding":false},{"id":1575487,"name":"J Young","orcid":null,"position":5,"is_corresponding":false},{"id":1575482,"name":"D C Fang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability.","abstract":"<jats:p>AIM: To investigate the role of DNA microsatellite instability (MSI) in gastric carcinogenesis by studying associations between MSI status, clinicopathological features, and loss of genetic loci. METHODS: Six microsatellite loci and loss of heterozygosity at APC, DCC, and MCC were analysed by polymerase chain reaction based methods in 53 cases of advanced gastric cancer. RESULTS: MSI was observed in 32.1% of gastric carcinomas (17/53) and 20% of foci of intestinal metaplasia (3/15). Seven gastric carcinomas (13.7%) were MSI-high (MSI-H) (three loci or more) and 10 (18.9%) were MSI-low (MSI-L) (one or two loci). The frequency of MSI-H was higher in intestinal (25.0%) than in diffuse carcinomas (3.7%) (p &lt; 0.05). None of the MSI-H tumours showed loss of heterozygosity at APC, MCC, or DCC loci. CONCLUSIONS: MSI may have an important and early role in a subset of gastric cancers, particularly the intestinal type. The MSI-H subset of gastric cancer has features in common with its colorectal counterpart, whereas MSI-L and microsatellite stable cancers appear to develop through the loss of heterozygosity pathway.</jats:p>","is_dataset_classified":null,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10605402","pmcid":"PMC501490","openalex_id":"https://openalex.org/W2166534946","authors":[],"funders":[],"total_grants":0,"fwci":1.6663,"citation_percentile":0.83704581,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":2},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://jcp.bmj.com/content/jclinpath/52/7/504.full.pdf","host_type":"journal"},{"url":"https://jcp.bmj.com/content/jclinpath/52/7/504.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1136/jcp.52.7.504","host_type":"publisher"},{"url":"https://doi.org/10.1136/jcp.52.7.504","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10605402","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/501490","host_type":"repository"}],"fields_of_study":["Genetic factors in colorectal cancer","Digestive system and related health","Genomic variations and chromosomal abnormalities","Adult","Aged","Chi-Square Distribution","Chromosomes, Human, Pair 18","Chromosomes, Human, Pair 5","Female","Genes, APC","Genes, DCC","Genes, MCC","Genes, Tumor Suppressor","Humans","Loss of Heterozygosity","Male","Microsatellite Repeats","Middle Aged","Polymerase Chain Reaction","Stomach Neoplasms"],"mesh_terms":["Adult","Aged","Chromosomes, Human, Pair 18","Chromosomes, Human, Pair 5","Female","Humans","Male","Middle Aged","Stomach Neoplasms","Chi-Square Distribution","Polymerase Chain Reaction","Genes, Tumor Suppressor","Genes, DCC","Genes, MCC","Genes, APC","Microsatellite Repeats","Loss of Heterozygosity"],"keywords":["Loss of heterozygosity","Microsatellite instability","Microsatellite","Cancer","Genetics","Biology","DNA","Gene","Cancer research","Computational biology","Allele"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T00:38:27.077148Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}