{"doi":"10.1136/fn.82.3.f224","title":"Anoxic ATP depletion in neonatal mice brainstem is prevented by creatine supplementation","abstract":"<jats:sec>\n                  <jats:title>BACKGROUND</jats:title>\n                  <jats:p>Sufficient ATP concentrations maintain physiological processes and protect tissue from hypoxic damage. With decreasing oxygen concentration, ATP synthesis relies increasingly on the presence of phosphocreatine.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>AIM</jats:title>\n                  <jats:p>The effect of exogenously applied creatine on phosphocreatine and ATP concentrations was studied under control and anoxic conditions.</jats:p>\n               </jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS</jats:title>\n                  <jats:p>Pregnant mice were fed orally with creatine monohydrate (2 g/kg body weight/day). Brainstem slices from these mice pups were compared with those from pups of non-creatine supplemented pregnant mice. Measurements were performed under normoxic and anoxic conditions. In addition, brainstem slices from non-creatine treated mice pups were incubated for 3 hours in control artificial cerebrospinal fluid (CSF) (n = 10) or in artificial CSF containing 200 μM creatine (n = 10). ATP and phosphocreatine contents were determined enzymatically in single brainstem slices.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS</jats:title>\n                  <jats:p>ATP concentrations were in the same range in all preparations. However, there was a significant increase of phosphocreatine in the brainstems from pups of creatine fed mice when compared with the brainstems of pups from non-creatine treated mice or in non-incubated brainstems of control animals. After 30 minutes anoxia, ATP as well as phosphocreatine concentrations remained significantly higher in creatine pretreated slices compared with controls.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION</jats:title>\n                  <jats:p>The data indicate that exogenous application of creatine is effective in neuroprotection.</jats:p>\n               </jats:sec>","journal":"Archives of Disease in Childhood - Fetal and Neonatal Edition","year":2000,"id":15823,"datarank":2.4175056534557164,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":1.8164056756708458,"self_endowment_contribution":0.6010999777848708,"citer_contribution":1.8164056756708458,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":54,"citers_with_citation_signal":47,"citers_with_endowment":47,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119189,"name":"J M Ramirez","orcid":null,"position":1,"is_corresponding":false},{"id":119190,"name":"I Probst","orcid":null,"position":2,"is_corresponding":false},{"id":119191,"name":"D W Richter","orcid":null,"position":3,"is_corresponding":false},{"id":119192,"name":"F Hanefeld","orcid":null,"position":4,"is_corresponding":false},{"id":119188,"name":"B Wilken","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10794791","pmcid":"PMC1721092","openalex_id":"https://openalex.org/W2151760453","authors":[],"funders":[],"total_grants":0,"fwci":1.7917,"citation_percentile":0.84258271,"influential_citations":3,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":5},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://fn.bmj.com/content/fetalneonatal/82/3/F224.full.pdf","host_type":"journal"},{"url":"https://fn.bmj.com/content/fetalneonatal/82/3/F224.full.pdf","host_type":"BRONZE"},{"url":"https://fn.bmj.com/content/fetalneonatal/82/3/F224.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1136/fn.82.3.F224","host_type":"publisher"},{"url":"https://doi.org/10.1136/fn.82.3.f224","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10794791","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1721092","host_type":"repository"}],"fields_of_study":["Muscle metabolism and nutrition","Neonatal and fetal brain pathology","Metabolism and Genetic Disorders","Medicine","Biology","Adenosine Triphosphate","Administration, Oral","Animals","Animals, Newborn","Brain Stem","Creatine","Female","Hypoxia, Brain","Mice","Neuroprotective Agents","Phosphocreatine","Pregnancy"],"mesh_terms":["Adenosine Triphosphate","Administration, Oral","Animals","Animals, Newborn","Brain Stem","Hypoxia, Brain","Creatine","Female","Phosphocreatine","Pregnancy","Neuroprotective Agents","Mice"],"keywords":["Phosphocreatine","Creatine","Internal medicine","Endocrinology","Brainstem","Anoxic waters","Creatine kinase","Chemistry","Medicine","Biology","Energy metabolism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T19:06:26.862615Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}