{"doi":"10.1136/bmjopen-2022-063141","title":"Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study","abstract":"OBJECTIVES: Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work. DESIGN: Cohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset. SETTING: Health systems in 12 US states. PARTICIPANTS: HCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset. EXPOSURES: Two doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine. MAIN OUTCOME MEASURES: Prevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work. RESULTS: Among 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79). CONCLUSIONS: Receipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work.","journal":"BMJ Open","year":2023,"id":330935,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459443,"name":"Ian D. Plumb","orcid":"0000-0003-4747-381X","position":1,"is_corresponding":false},{"id":411328,"name":"Karisa K. Harland","orcid":"0000-0001-9482-8447","position":2,"is_corresponding":false},{"id":327422,"name":"Tamara Pilishvili","orcid":null,"position":3,"is_corresponding":false},{"id":264787,"name":"Katherine E. Fleming-Dutra","orcid":"0000-0002-4862-0650","position":4,"is_corresponding":false},{"id":412567,"name":"Anusha Krishnadasan","orcid":null,"position":5,"is_corresponding":false},{"id":24973,"name":"Karin F. Hoth","orcid":"0000-0002-4261-5308","position":6,"is_corresponding":false},{"id":265850,"name":"Sharon Saydah","orcid":"0000-0002-6350-5300","position":7,"is_corresponding":false},{"id":1055737,"name":"Zachary Mankoff","orcid":null,"position":8,"is_corresponding":false},{"id":411340,"name":"John P. Haran","orcid":"0000-0001-7311-1121","position":9,"is_corresponding":false},{"id":525932,"name":"Melissa Briggs‐Hagen","orcid":null,"position":10,"is_corresponding":false},{"id":925104,"name":"Eliezer Santos León","orcid":null,"position":11,"is_corresponding":false},{"id":411335,"name":"David A. Talan","orcid":"0000-0002-7048-8086","position":12,"is_corresponding":false},{"id":411327,"name":"Nicholas M. Mohr","orcid":"0000-0003-0497-5828","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:09:14.691473Z","pmid":"36731936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}