{"doi":"10.1136/bmj.m3987","title":"Appraisal needs to re-start now so doctors can reflect on coronavirus experiences","abstract":null,"journal":"BMJ","year":2020,"id":645272,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1680080,"name":"Graham Layer","orcid":null,"position":1,"is_corresponding":false},{"id":1680081,"name":"Regi Alexander","orcid":null,"position":2,"is_corresponding":false},{"id":1680082,"name":"Vicky Banks","orcid":null,"position":3,"is_corresponding":false},{"id":1680083,"name":"Stephen Barasi","orcid":null,"position":4,"is_corresponding":false},{"id":1680084,"name":"Susan Bews","orcid":null,"position":5,"is_corresponding":false},{"id":1680085,"name":"Basant Chaudhury","orcid":null,"position":6,"is_corresponding":false},{"id":1680086,"name":"Philippa Cockman","orcid":null,"position":7,"is_corresponding":false},{"id":1680087,"name":"Maurice Conlon","orcid":null,"position":8,"is_corresponding":false},{"id":1680088,"name":"Sunil Dasan","orcid":null,"position":9,"is_corresponding":false},{"id":1680089,"name":"Tony Feltbower","orcid":null,"position":10,"is_corresponding":false},{"id":923984,"name":"David Fox","orcid":"0000-0003-1116-9576","position":11,"is_corresponding":false},{"id":1680090,"name":"Steph Hughes","orcid":null,"position":12,"is_corresponding":false},{"id":1680091,"name":"Bov Jani","orcid":null,"position":13,"is_corresponding":false},{"id":1680092,"name":"Di Jelley","orcid":null,"position":14,"is_corresponding":false},{"id":1680093,"name":"Nick Lewis-Barned","orcid":null,"position":15,"is_corresponding":false},{"id":1680094,"name":"Sol Mead","orcid":null,"position":16,"is_corresponding":false},{"id":1016031,"name":"Kashif Qureshi","orcid":"0009-0002-7734-0567","position":17,"is_corresponding":false},{"id":1680095,"name":"Paul Twomey","orcid":null,"position":18,"is_corresponding":false},{"id":1680096,"name":"Hugo van Woerden","orcid":null,"position":19,"is_corresponding":false},{"id":1680097,"name":"John Woodhouse","orcid":null,"position":20,"is_corresponding":false},{"id":1680098,"name":"Frances Yuille","orcid":null,"position":21,"is_corresponding":false},{"id":1680079,"name":"Susi Caesar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Appraisal needs to re-start now so doctors can reflect on coronavirus experiences","abstract":"<h3>Abstract</h3> <h3>Background</h3> Respiratory diseases such as chronic obstructive pulmonary disease (COPD) have been associated with increased risk of severe SARS-CoV-2 infection, but the mechanisms and putative immune pathways are unclear. Besides, increased levels of several immune mediators in patients with severe coronavirus disease 19 (COVID-19) have been reported. <h3>Objective</h3> To perform an immunoproteomic profiling of dysregulated plasma proteins in patients with asthma and COPD and to evaluate their relationship with biomarkers of severe COVID-19. <h3>Methods</h3> 92 protein biomarkers were quantified in 315 plasma samples from adult subjects (age 40-90 years) including 118 asthmatics, 99 COPD patients and 98 healthy controls, that have been recruited in two reference pneumology clinics in Colombia before the beginning of the COVID-19 pandemic. <h3>Results</h3> Forty-one plasma proteins showed differences between patients and controls. Asthmatic patients have increased levels in IL-6 and CCL3 while COPD patients have a broader systemic inflammatory dysregulation driven by HGF, OPG, and several chemokines (CXCL9, CXCL10, CXCL11, CX3CL1, CXCL1, MCP-3, MCP-4, CCL3, CCL4 and CCL11). Functional annotation revealed their enrichment in chemokine signaling pathways related with response to viral infections. Some of these proteins were found up-regulated upon SARS-Cov-2 infection of Calu-3 cells. Also, HPG, CXCL9, CXCL10, IL-6, MCP-3, TNF and EN-RAGE have been found increased in patients with severe COVID-19. HGF, the most significant protein in this study as well as its correlated proteins could be associated with the increased risk of severe COVID-19 in COPD patients. <h3>Conclusions</h3> Asthma and COPD patients have altered plasma levels of proteins that have been found associated with increased risk of severe COVID-19. The reasons for sharing these profiles with this infection are unknown, but our study suggest that adult patients with asthma and COPD have a systemic dysregulation in chemokine networks that could make them more susceptible to severe COVID-19.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33077426","pmcid":null,"openalex_id":"https://openalex.org/W3093455902","authors":[],"funders":[],"total_grants":0,"fwci":0.0242,"citation_percentile":0.38946781,"influential_citations":0,"citation_trend":[{"year":2020,"count":1}],"oa_status":"closed","license":"http://www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy","oa_locations":[{"url":"http://data.bmj.org/tdm/10.1136/bmj.m3987","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1136/bmj.m3987","host_type":"publisher"},{"url":"https://doi.org/10.1136/bmj.m3987","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33077426","host_type":"repository"},{"url":"http://www.bmj.com/cgi/content/short/371/oct19_1/m3987","host_type":"repository"}],"fields_of_study":["COVID-19 Clinical Research Studies","Respiratory Support and Mechanisms","Long-Term Effects of COVID-19"],"mesh_terms":["Betacoronavirus","COVID-19","SARS-CoV-2","Clinical Competence","Humans","Licensure, Medical","Physicians","Pneumonia, Viral","Quality Assurance, Health Care","Coronavirus Infections","Needs Assessment","Pandemics"],"keywords":["CXCL9","CXCL10","CCL11","COPD","Medicine","Chemokine","Immunology","Immune system","Asthma","Internal medicine","CCL2"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T04:15:10.336959Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}