{"doi":"10.1136/bmj.4.5834.232-b","title":"Anesthesia by acupuncture.","abstract":null,"journal":"BMJ","year":1972,"id":590005,"datarank":0.2977396007434131,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.05632391387829801,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.05632391387829801,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1509592,"name":"S G Hamilton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anesthesia by acupuncture.","abstract":"<h3>Summary</h3> Progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington’s disease (HD), but direct relationships between the huntingtin (HTT) protein and chromatin remain poorly described. Here, using chromatin immunoprecipitation and sequencing (ChIP-seq), we show that HTT reproducibly occupies specific locations in the mouse genome, including thousands of genomic loci that are differentially occupied in striatal tissue from a knock-in mouse model of HD (B6.<i>Htt<sup>Q111/+</sup></i>) versus wildtype controls. ChIP-seq of histone modifications, generated in parallel, revealed genotype-specific colocalization of HTT with trimethylation of histone 3 lysine 27 (H3K27me3), a repressive chromatin mark. Near genes that are differentially regulated in HD, greater HTT occupancy in <i>Htt<sup>Q111/+</sup></i> vs. wildtype mice predicted increased H3K27me3, reduced histone 3 lysine 4 (H3K4me3), a marker of poised and active promoters, and down-regulated gene expression. Altered huntingtin-chromatin interactions may therefore play a direct role in driving transcriptional dysregulation in HD.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"5082562","pmcid":"PMC1786451","openalex_id":"https://openalex.org/W2040110263","authors":[],"funders":[],"total_grants":0,"fwci":0.1616,"citation_percentile":0.3653744,"influential_citations":0,"citation_trend":[{"year":2018,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.bmj.com/content/bmj/4/5834/232.3.full.pdf","host_type":"journal"},{"url":"https://www.bmj.com/content/bmj/4/5834/232.3.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1136/bmj.4.5834.232-b","host_type":"publisher"},{"url":"https://doi.org/10.1136/bmj.4.5834.232-b","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/5082562","host_type":"repository"},{"url":"http://www.bmj.com/cgi/content/short/4/5834/232-b","host_type":"repository"}],"fields_of_study":["Genetic Neurodegenerative Diseases","Acupuncture Therapy","Anesthesia","Breathing Exercises","China","Female","Gastrectomy","Humans","Lung"],"mesh_terms":["Anesthesia","Breathing Exercises","China","Female","Gastrectomy","Humans","Lung","Acupuncture Therapy"],"keywords":["H3K4me3","Chromatin immunoprecipitation","Chromatin","Histone","Epigenetics","Biology","Huntingtin","Histone H3","Histone methylation","Genetics","Molecular biology","Gene expression","Promoter","Gene","DNA methylation","Mutant"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T12:12:44.669738Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}