{"doi":"10.1136/bmj.3.5924.152","title":"Plasma TSH and Serum T-4 Levels in Long-term Follow-up of Patients Treated with\n                    <sup>131</sup>\n                    I for Thyrotoxicosis","abstract":"<jats:p>In February 1972 58% of patients euthyroid after iodine-131 therapy given for thyrotoxicosis between 1954 and 1966 had a high plasma TSH (&gt;7·4 μU/ml) and 42% a normal plasma TSH level. A group of 69 of the euthyroid patients with high plasma TSH levels (25·0±2·0 μU/ml) in 1972 were re-examined 15 and 24 months later. The mean plasma TSH in the 66 patients remaining euthyroid at 15 months was 22·6±1·8 μU/ml, while three patients had become hypothyroid. At 24 months 64 of the patients were still available for study, of whom 61 remained euthyroid with a mean plasma TSH of 21·6±2·0 μU/ml, and a further three had become hypothyroid.</jats:p>\n                  <jats:p>All of a group of 61 of the euthyroid patients with normal plasma TSH levels (4·0±0·2 μU/ml) in 1972 remained euthyroid at 24 months with a mean plasma TSH of 4·1±0·3 μU/ml, though the plasma TSH level had become slightly raised in three.</jats:p>\n                  <jats:p>The mean serum T-4 level in the euthyroid patients with a high plasma TSH was significantly lower, though still in the normal range, than that in the euthyroid patients with a normal plasma TSH both in 1972 and in 1974.</jats:p>\n                  <jats:p>Since no patient with a normal plasma TSH level after iodine-131 treatment six to 18 years earlier for thyrotoxicosis developed hypothyroidism over a two-year period, the follow-up of such patients need not be so rigorous as that of similarly treated euthyroid patients with raised plasma TSH levels in whom hypothyroidism developed at the rate of 5% per year.</jats:p>","journal":"BMJ","year":1974,"id":30023,"datarank":2.078771464582885,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":1.6084473321935127,"self_endowment_contribution":0.47032413238937254,"citer_contribution":1.6084473321935127,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":19,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":164116,"name":"W. J. Irvine","orcid":null,"position":1,"is_corresponding":false},{"id":164117,"name":"W. M. Hunter","orcid":null,"position":2,"is_corresponding":false},{"id":164118,"name":"J. Seth","orcid":null,"position":3,"is_corresponding":false},{"id":164115,"name":"A. D. Toft","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4136163","pmcid":"PMC1611292","openalex_id":"https://openalex.org/W2076604216","authors":[],"funders":[],"total_grants":0,"fwci":3.1717,"citation_percentile":0.90866397,"influential_citations":1,"citation_trend":[],"oa_status":"bronze","license":"http://www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy","oa_locations":[{"url":"https://www.bmj.com/content/bmj/3/5924/152.full.pdf","host_type":"journal"},{"url":"https://www.bmj.com/content/bmj/3/5924/152.full.pdf","host_type":"BRONZE"},{"url":"https://www.bmj.com/content/bmj/3/5924/152.full.pdf","host_type":"publisher"},{"url":"http://data.bmj.org/tdm/10.1136/bmj.3.5924.152","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1136/bmj.3.5924.152","host_type":"publisher"},{"url":"https://doi.org/10.1136/bmj.3.5924.152","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4136163","host_type":"repository"},{"url":"http://www.bmj.com/cgi/content/short/3/5924/152","host_type":"repository"}],"fields_of_study":["Thyroid Disorders and Treatments","Thyroid Cancer Diagnosis and Treatment","Medicine","Follow-Up Studies","Humans","Hyperthyroidism","Hypothyroidism","Iodine Radioisotopes","Radioimmunoassay","Radiotherapy","Thyroid Function Tests","Thyrotropin","Thyroxine"],"mesh_terms":["Follow-Up Studies","Humans","Hyperthyroidism","Hypothyroidism","Iodine Radioisotopes","Radioimmunoassay","Radiotherapy","Thyroid Function Tests","Thyrotropin","Thyroxine"],"keywords":["Euthyroid","Internal medicine","Medicine","Endocrinology","Iodine","Plasma levels","Wolff–Chaikoff effect","Thyroid","Gastroenterology","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T01:39:06.247202Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}