{"doi":"10.1136/bjsports-2022-106445","title":"Association between physical activity and the time course of cancer recurrence in stage III colon cancer","abstract":"OBJECTIVE: We determined if postoperative physical activity prevents or delays cancer recurrence in patients with stage III colon cancer. METHODS: This cohort study nested within a randomised trial enrolled 1696 patients with surgically resected stage III colon cancer. Physical activity was calculated based on self-reporting during and after chemotherapy. Patients were classified as physically active (≥9 MET-h/wk, comparable with the energy expenditure of 150 min/wk of brisk walking, consistent with the current physical activity guidelines for cancer survivors) or physically inactive (<9 MET-h/wk). The confounder-adjusted hazard rate (risk of recurrence or death) and HR by physical activity category were estimated with continuous time to allow non-proportionality of hazards. RESULTS: During a median 5.9 years follow-up, 457 patients experienced disease recurrence or death. For physically active and physically inactive patients, the risk of disease recurrence peaked between 1 and 2 years postoperatively and declined gradually to year 5. The risk of recurrence in physically active patients never exceeded that of physically inactive patients during follow-up, suggesting that physical activity prevents-as opposed to delays-cancer recurrence in some patients. A statistically significant disease-free survival benefit associated with physical activity was observed during the first postoperative year (HR 0.68, 95% CI 0.51 to 0.92). A statistically significant overall survival benefit associated with physical activity was observed during the first three postoperative years (HR 0.32, 95% CI 0.19 to 0.51). CONCLUSIONS: In this observational study of patients with stage III colon cancer, postoperative physical activity is associated with improved disease-free survival by lowering the recurrence rate within the first year of treatment, which translates into an overall survival benefit.","journal":"British Journal of Sports Medicine","year":2023,"id":331931,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9447,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":668048,"name":"Chao Ma","orcid":"0000-0001-7741-818X","position":1,"is_corresponding":false},{"id":310795,"name":"Qian Shi","orcid":"0000-0002-4640-8832","position":2,"is_corresponding":false},{"id":429764,"name":"Donna Niedzwiecki","orcid":"0000-0002-3566-0450","position":3,"is_corresponding":false},{"id":556231,"name":"Tyler Zemla","orcid":"0009-0005-2390-3557","position":4,"is_corresponding":false},{"id":567925,"name":"Félix Couture","orcid":null,"position":5,"is_corresponding":false},{"id":1054937,"name":"Philip Kuebler","orcid":"0009-0004-0964-2971","position":6,"is_corresponding":false},{"id":552666,"name":"Pankaj Kumar","orcid":"0000-0003-4284-6787","position":7,"is_corresponding":false},{"id":550347,"name":"Judith O. Hopkins","orcid":"0000-0002-9829-1242","position":8,"is_corresponding":false},{"id":291476,"name":"Benjamin Kye Jyn Tan","orcid":"0000-0002-9411-6164","position":9,"is_corresponding":false},{"id":262241,"name":"Smitha Krishnamurthi","orcid":"0000-0003-2411-3504","position":10,"is_corresponding":false},{"id":242198,"name":"Eileen M. O’Reilly","orcid":"0000-0002-8076-9199","position":11,"is_corresponding":false},{"id":254340,"name":"Anthony F. Shields","orcid":"0000-0002-9122-1014","position":12,"is_corresponding":false},{"id":6441,"name":"Jeffrey A. Meyerhardt","orcid":"0000-0002-1120-0898","position":13,"is_corresponding":false},{"id":273715,"name":"Justin C. Brown","orcid":"0000-0001-7540-4913","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:09:25.015646Z","pmid":"36878665","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}