{"doi":"10.1136/bjo-2022-321889","title":"Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy","abstract":"BACKGROUND: We report visual outcomes and ocular complications in patients with lacrimal gland carcinoma who had eye-sparing surgery followed by radiotherapy. METHODS: This review included consecutive patients with lacrimal gland carcinoma who underwent eye-sparing surgery and adjuvant radiotherapy or concurrent chemoradiation therapy between 2007 and 2018. Clinical data, including details of ophthalmological examinations and radiation treatment were reviewed. RESULTS: The study included 23 patients, 15 males and 8 females, with median age 51 years. Twenty patients (87%) received intensity-modulated proton therapy; 3 (13%) received intensity-modulated radiotherapy. Nineteen patients (83%) received concurrent chemotherapy. After a median follow-up time of 37 months (range: 8-83), 13 patients (57%) had best-corrected visual acuity 20/40 or better, 3 (13%) had moderate vision loss (between 20/40 and 20/200) and 7 (30%) had severe vision loss (20/200 or worse). The most common ocular complications were dry eye disease (21 patients; 91%), radiation retinopathy (16; 70%) and cataract progression (11; 49%). Tumour crossing the orbital midline (p=0.014) and Hispanic ethnicity (p=0.014) were associated with increased risk of severe vision loss. The risk of radiation retinopathy was significantly different among the three racial groups; Hispanic patients (n=3) had the highest rate of retinopathy (p<0.001). Tumour size, initial T category and total prescribed radiation dose were not significantly associated with severe vision loss. CONCLUSION: Eye-sparing surgery followed by adjuvant radiotherapy in patients with lacrimal gland carcinoma has a reasonable overall visual prognosis. Patients with tumours crossing the orbital midline and Hispanic patients have a higher risk of severe vision loss.","journal":"British Journal of Ophthalmology","year":2022,"id":266780,"datarank":0.4221330815983171,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.07674531764921019,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.07674531764921019,"corpus_percentile":56.06869343235089,"corpus_rank":5680,"citation_count":9,"citer_count":5,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348525,"name":"Steven J. Frank","orcid":"0000-0001-6517-7884","position":1,"is_corresponding":false},{"id":232859,"name":"Jing Ning","orcid":"0000-0002-5289-331X","position":2,"is_corresponding":false},{"id":743355,"name":"Jiawei Zhao","orcid":"0000-0002-1625-1176","position":3,"is_corresponding":false},{"id":926903,"name":"Xinyang Jiang","orcid":"0000-0002-4991-0596","position":4,"is_corresponding":false},{"id":407909,"name":"Xin A. Wang","orcid":null,"position":5,"is_corresponding":false},{"id":444038,"name":"Amy C Schefler","orcid":"0000-0001-9829-8164","position":6,"is_corresponding":false},{"id":927340,"name":"Ehab Hanna","orcid":null,"position":7,"is_corresponding":false},{"id":346829,"name":"Amy C. Moreno","orcid":"0000-0001-6762-6807","position":8,"is_corresponding":false},{"id":351189,"name":"G. Brandon Gunn","orcid":"0000-0001-8197-0380","position":9,"is_corresponding":false},{"id":244404,"name":"Renata Ferrarotto","orcid":"0000-0002-3561-215X","position":10,"is_corresponding":false},{"id":69929,"name":"Bita Esmaeli","orcid":"0000-0002-3667-1821","position":11,"is_corresponding":false},{"id":926902,"name":"Zhenyang Zhao","orcid":"0000-0002-1701-3751","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T00:26:58.102271Z","pmid":"36229179","pmcid":"PMC10097836","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}