{"doi":"10.1128/spectrum.05236-22","title":"Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline","abstract":"Drug resistance necessitates the development of new antimalarial drugs. It is important to assess the activities of compounds under development against parasites now causing disease in Africa, where most malaria cases occur, and to determine if mutations in these parasites may limit the efficacies of new agents. We found that African isolates were generally highly susceptible to the 19 studied lead antimalarials. Sequencing of the presumed drug targets identified multiple mutations in these genes, but these mutations were generally not associated with decreased antimalarial activity. These results offer confidence that the activities of the tested antimalarial compounds now under development will not be limited by preexisting resistance-mediating mutations in African malaria parasites.","journal":"Microbiology Spectrum","year":2023,"id":359348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242450,"name":"Patrick K. Tumwebaze","orcid":"0000-0002-5933-1432","position":1,"is_corresponding":false},{"id":646374,"name":"Martin Okitwi","orcid":"0000-0003-2712-2174","position":2,"is_corresponding":false},{"id":647236,"name":"Stephen Orena","orcid":null,"position":3,"is_corresponding":false},{"id":647235,"name":"Oswald Byaruhanga","orcid":null,"position":4,"is_corresponding":false},{"id":528692,"name":"Thomas Katairo","orcid":"0000-0002-2002-8911","position":5,"is_corresponding":false},{"id":242447,"name":"Melissa D. Conrad","orcid":"0000-0002-9984-8030","position":6,"is_corresponding":false},{"id":647239,"name":"Stephanie A. Rasmussen","orcid":null,"position":7,"is_corresponding":false},{"id":244078,"name":"Jennifer Legac","orcid":null,"position":8,"is_corresponding":false},{"id":242448,"name":"Özkan Aydemir","orcid":"0000-0002-3458-6527","position":9,"is_corresponding":false},{"id":845585,"name":"David Giesbrecht","orcid":"0000-0003-2498-4705","position":10,"is_corresponding":false},{"id":587298,"name":"Barbara Forte","orcid":"0000-0003-3986-5880","position":11,"is_corresponding":false},{"id":13084,"name":"Peter J. Campbell","orcid":"0000-0002-3921-0510","position":12,"is_corresponding":false},{"id":673290,"name":"Alasdair Smith","orcid":null,"position":13,"is_corresponding":false},{"id":1110315,"name":"Hiroki Kano","orcid":null,"position":14,"is_corresponding":false},{"id":242455,"name":"Samuel L. Nsobya","orcid":"0000-0003-4986-8823","position":15,"is_corresponding":false},{"id":632936,"name":"Benjamin Blasco","orcid":"0000-0002-1485-7887","position":16,"is_corresponding":false},{"id":632935,"name":"Maëlle Duffey","orcid":"0000-0002-4319-0647","position":17,"is_corresponding":false},{"id":242456,"name":"Jeffrey A. Bailey","orcid":"0000-0002-6899-8204","position":18,"is_corresponding":false},{"id":242451,"name":"Roland A. Cooper","orcid":"0000-0002-8437-9382","position":19,"is_corresponding":false},{"id":242457,"name":"Philip J. Rosenthal","orcid":"0000-0002-7953-7622","position":20,"is_corresponding":false},{"id":738607,"name":"Oriana Kreutzfeld","orcid":"0000-0003-2026-345X","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"37158739","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}