{"doi":"10.1128/spectrum.04974-22","title":"Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis","abstract":"Mycobacterium tuberculosis, the causative agent of tuberculosis, is a serious global health problem requiring the development of new therapeutics. We previously ran a high-throughput screen and identified a series of compounds with antitubercular activity. In this paper, we test analogs of our hit molecules for activity against M. tuberculosis, as well as for activity against eukaryotic cells. We identified molecules with improved selectivity. Our molecules killed both replicating and nonreplicating bacteria but did not work by targeting protein secretion.","journal":"Microbiology Spectrum","year":2023,"id":352257,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1098203,"name":"Jo-Ann Jee","orcid":null,"position":1,"is_corresponding":false},{"id":1098204,"name":"Somsundaram Chettiar","orcid":null,"position":2,"is_corresponding":false},{"id":1000262,"name":"Yulia Ovechkina","orcid":null,"position":3,"is_corresponding":false},{"id":693065,"name":"Aaron Korkegian","orcid":null,"position":4,"is_corresponding":false},{"id":1098205,"name":"Eric Greve","orcid":null,"position":5,"is_corresponding":false},{"id":693069,"name":"Joshua Odingo","orcid":null,"position":6,"is_corresponding":false},{"id":490973,"name":"Tanya Parish","orcid":"0000-0001-7507-0423","position":7,"is_corresponding":false},{"id":490972,"name":"Shilah A. Bonnett","orcid":"0000-0003-4678-6566","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:12:50.107998Z","pmid":"36688635","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}