{"doi":"10.1128/spectrum.04500-22","title":"<i>Neisseria gonorrhoeae</i> Coinfection during <i>Chlamydia muridarum</i> Genital Latency Does Not Modulate Murine Vaginal Bacterial Shedding","abstract":"Our work builds upon the limited understanding of C. muridarum/N. gonorrhoeae coinfection. Previously, N. gonorrhoeae infection of mice with acute (actively replicating) vaginal C. muridarum infection was shown to increase recovery of viable vaginal N. gonorrhoeae and vaginal PMNs, with no effect on C. muridarum vaginal shedding (R. A. Vonck et al., Infect Immun 79:1566-1577, 2011). It has also been shown that chlamydial infection of human and murine PMNs prevents normal PMN responses, including the response to N. gonorrhoeae (K. Rajeeve et al., Nat Microbiol 3:824-835, 2018). Our findings show no effect of latent genital C. muridarum infection on the recovery of viable N. gonorrhoeae, in contrast to the previously reported effect of acute C. muridarum infection, and suggesting that acute versus latent C. muridarum infection may have distinct effects on PMN function in mice. Together, these studies to date provide evidence that Chlamydia/N. gonorrhoeae synergistic interactions may depend on the presence of replicating Chlamydia in the genital tract, while chlamydial effects on vaginal PMNs may extend beyond acute infection.","journal":"Microbiology Spectrum","year":2023,"id":370978,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1130273,"name":"Cory Ann Leonard","orcid":"0000-0003-0711-5006","position":1,"is_corresponding":false},{"id":1130274,"name":"Regenia B. Phillips Campbell","orcid":"0000-0001-7028-0499","position":2,"is_corresponding":false},{"id":1130650,"name":"Barbara Prähauser","orcid":null,"position":3,"is_corresponding":false},{"id":1130651,"name":"Theresa Pesch","orcid":null,"position":4,"is_corresponding":false},{"id":1130652,"name":"Robert V. Schoborg","orcid":null,"position":5,"is_corresponding":false},{"id":277694,"name":"Ann E. Jerse","orcid":"0000-0002-5118-3172","position":6,"is_corresponding":false},{"id":1130653,"name":"Bernadetta Tarigan","orcid":null,"position":7,"is_corresponding":false},{"id":1130275,"name":"Nicole Borel","orcid":"0000-0002-1556-9262","position":8,"is_corresponding":false},{"id":1130272,"name":"Delia Onorini","orcid":"0000-0002-8783-837X","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:15:41.237096Z","pmid":"37039695","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}