{"doi":"10.1128/spectrum.04493-22","title":"Plasmodium falciparum Gametes and Sporozoites Hijack Plasmin and Factor H To Evade Host Complement Killing","abstract":"Current approaches to control malaria are complicated by the development of antimalarial-resistant parasites and insecticide-resistant vectors. Vaccines that block transmission to mosquitoes and humans are a plausible alternative to overcome these setbacks. To inform the development of efficacious vaccines, it is imperative to understand how the parasite interacts with the host immune response. In this report, we show that the parasite can co-opt host plasmin, a mammalian fibrinolytic protein to evade host complement attack. Our results highlight a potential mechanism that may reduce efficacy of potent vaccine candidates. Taken together, our results will inform future studies in developing novel antimalarial therapeutics.","journal":"Microbiology Spectrum","year":2023,"id":353835,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1100962,"name":"Thiago F. A. Rosa","orcid":null,"position":1,"is_corresponding":false},{"id":697684,"name":"Zarna Rajeshkumar Pala","orcid":"0000-0003-1201-1551","position":2,"is_corresponding":false},{"id":570595,"name":"Heather M. Kudyba","orcid":null,"position":3,"is_corresponding":false},{"id":775989,"name":"Brendan Sweeney","orcid":"0009-0008-9196-1240","position":4,"is_corresponding":false},{"id":1100510,"name":"Timo Reiß","orcid":"0000-0003-3559-1528","position":5,"is_corresponding":false},{"id":731177,"name":"Gabriele Pradel","orcid":"0000-0003-2264-5558","position":6,"is_corresponding":false},{"id":379183,"name":"Joel Vega-Rodríguez","orcid":"0000-0002-9576-0058","position":7,"is_corresponding":false},{"id":775988,"name":"Medard Ernest","orcid":"0000-0003-4332-3822","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:13:02.680107Z","pmid":"37191558","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}