{"doi":"10.1128/spectrum.04363-22","title":"SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice","abstract":"Vaccines have significantly reduced the incidences of severe coronavirus disease 2019 (COVID-19) cases and deaths. However, the emergence of SARS-CoV-2 variants has raised concerns about their increased transmissibility and ability to evade neutralizing antibodies, especially among elderly individuals who are at higher risks of mortality and reductions of vaccine effectiveness. To address this, a heterologous booster vaccination strategy has been considered as a solution to protect the elderly population against breakthrough infections caused by emerging variants. This study evaluated the booster effect of an S1 subunit vaccine in aged mice that had been previously primed with adenoviral vaccines, providing valuable preclinical evidence for elderly people vaccinated with the currently approved COVID-19 vaccines. This study confirms the potential for using the S1 subunit vaccine as a booster to enhance cross-neutralizing antibodies against emerging variants of concern.","journal":"Microbiology Spectrum","year":2023,"id":358442,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":915307,"name":"Muhammad S. Khan","orcid":"0000-0002-2783-7236","position":1,"is_corresponding":false},{"id":1018722,"name":"Alessandro Ferrari","orcid":"0000-0003-2397-7079","position":2,"is_corresponding":false},{"id":228846,"name":"Shaohua Huang","orcid":"0000-0003-2407-949X","position":3,"is_corresponding":false},{"id":628153,"name":"Josè Camilla Sammartino","orcid":"0000-0003-3707-3118","position":4,"is_corresponding":false},{"id":628141,"name":"Elena Percivalle","orcid":"0000-0002-3355-1410","position":5,"is_corresponding":false},{"id":229925,"name":"Thomas W. Kenniston","orcid":null,"position":6,"is_corresponding":false},{"id":628140,"name":"Irene Cassaniti","orcid":"0000-0002-3385-2088","position":7,"is_corresponding":false},{"id":628158,"name":"Fausto Baldanti","orcid":"0000-0002-3358-8969","position":8,"is_corresponding":false},{"id":228853,"name":"Andrea Gambotto","orcid":"0000-0001-8154-7419","position":9,"is_corresponding":false},{"id":1108536,"name":"Eun Kim","orcid":"0000-0001-7963-7722","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:13:43.629667Z","pmid":"37162333","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}