{"doi":"10.1128/spectrum.04312-22","title":"Pathogen Detection Using Metagenomic Next-Generation Sequencing of Plasma Samples from Patients with Sepsis in Uganda","abstract":"The use of next-generation sequencing (NGS) in blood samples is an emerging technology for clinical microbiology labs. In this work, we performed NGS on plasma samples from a well-characterized cohort, where all samples had been previously tested by PCR for 43 pathogens. Therefore, we could compare sequencing performance against that of PCR and identify clinical correlates. A broad range of potential pathogens were identified by metagenomic sequencing in patients with sepsis in Uganda, particularly viruses, which we confirmed by PCR. In addition to HIV viremia, unexpectedly high rates of hepatitis B and EBV viremia were found, which may have important clinical implications.","journal":"Microbiology Spectrum","year":2023,"id":357247,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506647,"name":"Hardik I. Parikh","orcid":"0000-0002-5621-7343","position":1,"is_corresponding":false},{"id":109930,"name":"Shevin T. Jacob","orcid":"0000-0003-2425-9394","position":2,"is_corresponding":false},{"id":1107120,"name":"Patrick Banura","orcid":null,"position":3,"is_corresponding":false},{"id":1107121,"name":"Chris C. Moore","orcid":null,"position":4,"is_corresponding":false},{"id":289247,"name":"Jie Liu","orcid":"0000-0003-2658-5249","position":5,"is_corresponding":false},{"id":289258,"name":"Eric R. Houpt","orcid":"0000-0003-1085-1354","position":6,"is_corresponding":false},{"id":672056,"name":"Brian Grundy","orcid":"0000-0003-2243-3395","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:13:34.795336Z","pmid":"36625651","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}