{"doi":"10.1128/spectrum.04093-22","title":"Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions","abstract":"Nontypeable Haemophilus influenzae (NTHi) is a predominant pathogen of the human airway that causes respiratory infections such as otitis media (OM) and exacerbations in the lungs of patients suffering from chronic obstructive pulmonary disease (COPD). Due to the lack of a licensed vaccine against NTHi and the emergence of antibiotic-resistant strains, it is extremely challenging to target NTHi for treatment. NTHi adhesins are considered potential candidates for vaccines or other therapeutic approaches. The ModA phasevarions of NTHi play a role in the rapid adaptation of the pathogen to different environmental stress conditions. This study addressed the role of ModA phasevarions in the regulation of adherence of NTHi to specific host substrates found within the respiratory tract. The findings of this study improve our understanding of regulation of adherence of NTHi to the airway, which may further be used to enhance the potential of adhesins as vaccine antigens and therapeutic targets against NTHi.","journal":"Microbiology Spectrum","year":2022,"id":276105,"datarank":0.4675564800207958,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.1221687160716889,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.1221687160716889,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.962,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":308664,"name":"John M. Atack","orcid":"0000-0002-7994-6995","position":1,"is_corresponding":false},{"id":946200,"name":"Brandon M. Wills","orcid":"0009-0004-3842-4914","position":2,"is_corresponding":false},{"id":308671,"name":"Michael P. Jennings","orcid":"0000-0002-1027-4684","position":3,"is_corresponding":false},{"id":407396,"name":"Lauren O. Bakaletz","orcid":"0000-0002-0017-1710","position":4,"is_corresponding":false},{"id":407395,"name":"Kenneth L. Brockman","orcid":"0000-0002-0339-7504","position":5,"is_corresponding":false},{"id":831031,"name":"Preeti Garai","orcid":"0000-0002-3713-6441","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:28:26.545826Z","pmid":"36511712","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}