{"doi":"10.1128/spectrum.03874-22","title":"Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum","abstract":"The intestinal parasite Cryptosporidium parvum is a major cause of diarrhea-associated morbidity and mortality in children, immunocompromised people, and young ruminant animals. With no effective drug available to treat cryptosporidiosis in humans and animals, there is an urgent need to identify anti-parasitic compounds and new targets for drug development. To address this unmet need, we screened a GSK library of kinase inhibitors and identified several potent compounds, including tyrosine kinase inhibitors, that were highly effective in killing C. parvum. Overall, our study revealed several novel compounds and a new family of kinases that can be targeted for anti-cryptosporidial drug development.","journal":"Microbiology Spectrum","year":2022,"id":279768,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":953346,"name":"Félix Calderón","orcid":"0000-0003-0486-6883","position":1,"is_corresponding":false},{"id":953347,"name":"Elena Fernández","orcid":"0000-0003-1624-8206","position":2,"is_corresponding":false},{"id":953348,"name":"Lluís Ballell","orcid":"0000-0002-3029-1860","position":3,"is_corresponding":false},{"id":953349,"name":"Paul Bamborough","orcid":"0000-0001-9479-2894","position":4,"is_corresponding":false},{"id":324510,"name":"Sumiti Vinayak","orcid":null,"position":5,"is_corresponding":false},{"id":324508,"name":"Maria G. Nava","orcid":null,"position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T00:28:55.546964Z","pmid":"36533912","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}