{"doi":"10.1128/spectrum.03646-22","title":"Diverse Sensory Repertoire of Paralogous Chemoreceptors Tlp2, Tlp3, and Tlp4 in <i>Campylobacter jejuni</i>","abstract":"Campylobacter jejuni responds to extracellular stimuli via transducer-like chemoreceptors (Tlps). This remarkable sensory perception mechanism allows bacteria to sense environmental changes and avoid unfavorable conditions or to maneuver toward nutrient sources and host cells. Here, we describe receptor-ligand interactions of a unique paralogue family of chemoreceptors, Tlp2, Tlp3, and Tlp4, that may have arisen through domain duplications, followed by a divergent evolutionary drift, with Tlp3 emerging more recently. Unlike previous reports of ligands interacting with sensory proteins, Tlp2, Tlp3, and Tlp4 responded to many types of chemical compounds, including simple and complex sugars such as those present on human blood group antigens and gangliosides, indicating a potential role in host-pathogen interactions. Diverse sensory repertoire could provide C. jejuni with the ability to modulate responses to attractant and repellent signals and allow for adaptation in host-pathogen interactions.","journal":"Microbiology Spectrum","year":2022,"id":272213,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":666797,"name":"Bassam A. Elgamoudi","orcid":"0000-0001-6372-5197","position":1,"is_corresponding":false},{"id":666798,"name":"Ekaterina P. Andrianova","orcid":"0000-0003-3719-0293","position":2,"is_corresponding":false},{"id":308663,"name":"Thomas Haselhorst","orcid":"0000-0002-3373-8680","position":3,"is_corresponding":false},{"id":308661,"name":"Christopher J. Day","orcid":"0000-0001-7953-4408","position":4,"is_corresponding":false},{"id":618464,"name":"Lauren E. Hartley‐Tassell","orcid":"0000-0003-2415-0321","position":5,"is_corresponding":false},{"id":667384,"name":"Rebecca M. King","orcid":null,"position":6,"is_corresponding":false},{"id":938750,"name":"Tahria Najnin","orcid":null,"position":7,"is_corresponding":false},{"id":317405,"name":"Igor B. Zhulin","orcid":"0000-0002-6708-5323","position":8,"is_corresponding":false},{"id":666800,"name":"Victoria Korolik","orcid":"0000-0002-5535-4151","position":9,"is_corresponding":false},{"id":667385,"name":"T. Taha","orcid":null,"position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:43.806977Z","pmid":"36374080","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}