{"doi":"10.1128/spectrum.03622-22","title":"HIV-1 Proteins gp120 and Tat Promote Epithelial-Mesenchymal Transition and Invasiveness of HPV-Positive and HPV-Negative Neoplastic Genital and Oral Epithelial Cells","abstract":"HPV-16-immortalized genital and oral epithelial cells and HPV-negative oral cancer cells that undergo prolonged contact with cell-free HIV-1 virions or with viral proteins gp120 and tat respond by becoming more invasive. EMT cells induced by HIV-1 in cultures of HPV-16-immortalized anal and cervical epithelial cells express the stem cell markers CD133 and CD44. These results suggest that the interaction of HIV-1 with neoplastic epithelial cells may lead to their de-differentiation into cancer stem cells that are resistant to apoptosis and anti-cancer drugs. Thus, this pathway may play a critical role in the development of invasive cancer. Inhibition of TGF-β1 and MAPK signaling and vimentin expression, and restoration of E-cadherin expression reduced HIV-induced EMT and the invasiveness of HPV-16-immortalized anal and cervical epithelial cells. Taken together, these results suggest that these approaches might be exploited to limit the role of HIV-1 infection in the acceleration of HPV-associated or HPV-independent epithelial neoplasia.","journal":"Microbiology Spectrum","year":2022,"id":254833,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":902529,"name":"Mayer Wasima","orcid":null,"position":1,"is_corresponding":false},{"id":902055,"name":"Rossana Herrera","orcid":"0009-0008-4071-7811","position":2,"is_corresponding":false},{"id":902530,"name":"Nicole T. Padilla","orcid":null,"position":3,"is_corresponding":false},{"id":902056,"name":"Xiaodan Cai","orcid":"0009-0005-8711-2041","position":4,"is_corresponding":false},{"id":902531,"name":"Vicky Lin","orcid":null,"position":5,"is_corresponding":false},{"id":902532,"name":"Rangsimon Pholcharoenchit","orcid":null,"position":6,"is_corresponding":false},{"id":265771,"name":"Joel M. Palefsky","orcid":"0000-0002-5097-3818","position":7,"is_corresponding":false},{"id":902057,"name":"Sharof M. Tugizov","orcid":"0000-0002-3743-4334","position":8,"is_corresponding":false},{"id":902054,"name":"Kathy Lien","orcid":"0000-0003-3253-9361","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:08.518416Z","pmid":"36314970","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}