{"doi":"10.1128/spectrum.03494-22","title":"Computed Tomography Imaging for Monitoring of Marburg Virus Disease: a Nonhuman Primate Proof-Of-Concept Study","abstract":"Marburg virus (MARV) is a highly virulent zoonotic filovirid that causes Marburg virus disease (MVD) in humans. Much is unknown about disease progression and, thus, prevention and treatment options are limited. Medical imaging modalities, such as whole-body computed tomography (CT), have the potential to improve understanding of MVD pathogenesis. Our study used CT to identify abnormalities in the liver, spleen, and axillary lymph nodes that corresponded to known clinical signs of MVD in this animal model. Our results indicated that CT imaging and analyses could be used to elucidate pathogenesis and possibly assess the efficacy of candidate treatments.","journal":"Microbiology Spectrum","year":2023,"id":374569,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107585,"name":"Ji Hyun Lee","orcid":"0000-0003-3810-9186","position":1,"is_corresponding":false},{"id":363585,"name":"Marcelo A. Castro","orcid":"0000-0003-3450-0989","position":2,"is_corresponding":false},{"id":545660,"name":"Jeffrey Solomon","orcid":"0000-0003-2711-1977","position":3,"is_corresponding":false},{"id":365289,"name":"Nina M. Aiosa","orcid":null,"position":4,"is_corresponding":false},{"id":365288,"name":"Syed M. S. Reza","orcid":null,"position":5,"is_corresponding":false},{"id":432729,"name":"Winston T. Chu","orcid":"0000-0001-7818-9139","position":6,"is_corresponding":false},{"id":420168,"name":"Joshua C. Johnson","orcid":"0000-0002-5677-3841","position":7,"is_corresponding":false},{"id":546296,"name":"Christopher Bartos","orcid":null,"position":8,"is_corresponding":false},{"id":606717,"name":"Kurt Cooper","orcid":"0000-0003-2941-8008","position":9,"is_corresponding":false},{"id":390603,"name":"Peter B. Jahrling","orcid":"0000-0002-9775-3724","position":10,"is_corresponding":false},{"id":232893,"name":"Reed F. Johnson","orcid":"0000-0002-4312-0550","position":11,"is_corresponding":false},{"id":106855,"name":"Claudia Calcagno","orcid":"0000-0002-4325-8728","position":12,"is_corresponding":false},{"id":109931,"name":"Ian Crozier","orcid":"0000-0003-2485-4011","position":13,"is_corresponding":false},{"id":109882,"name":"Jens H. Kuhn","orcid":"0000-0002-7800-6045","position":14,"is_corresponding":false},{"id":226712,"name":"Lisa E. Hensley","orcid":"0000-0003-1188-4342","position":15,"is_corresponding":false},{"id":363589,"name":"Irwin M. Feuerstein","orcid":"0000-0001-6670-5407","position":16,"is_corresponding":false},{"id":106854,"name":"Venkatesh Mani","orcid":"0000-0002-0432-2918","position":17,"is_corresponding":false},{"id":421273,"name":"Jennifer Sword","orcid":null,"position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T01:16:15.380731Z","pmid":"37036346","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}