{"doi":"10.1128/spectrum.01643-21","title":"Large Comparative Analyses of Primate Body Site Microbiomes Indicate that the Oral Microbiome Is Unique among All Body Sites and Conserved among Nonhuman Primates","abstract":"The microbiome is critical to host health and disease, but much remains unknown about the determinants, levels, and evolution of host-microbial diversity. The relationship between hosts and their associated microbes is complex. Most studies to date have focused on the gut microbiome; however, large gaps remain in our understanding of host-microbial diversity, coevolution, and levels of variation in microbiomes across multiple body sites and host species. To better understand the patterns of variation and evolutionary context of host-microbial communities, we conducted one of the largest comparative studies to date, which indicated that the oral microbiome was distinct from the microbiomes of all other body sites and convergent across host species, suggesting conserved niche specialization within the Primates order. We also show the importance of host species differences in shaping the microbiome within specific body sites. This large, comparative study contributes valuable information on key patterns of variation among hosts and body sites, with implications for understanding host-microbial dynamics and human-microbial coevolution.","journal":"Microbiology Spectrum","year":2022,"id":258660,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.938,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":669860,"name":"Lawrence Mugisha","orcid":"0000-0003-4932-3356","position":1,"is_corresponding":false},{"id":910222,"name":"Joshua Rukundo","orcid":"0009-0003-5054-417X","position":2,"is_corresponding":false},{"id":910223,"name":"Rebecca J. Lewis","orcid":"0000-0003-3533-6105","position":3,"is_corresponding":false},{"id":369856,"name":"Ali Halajian","orcid":"0000-0003-2279-940X","position":4,"is_corresponding":false},{"id":179339,"name":"Liliana Cortés‐Ortiz","orcid":"0000-0002-1197-6362","position":5,"is_corresponding":false},{"id":829545,"name":"Randall E. Junge","orcid":"0000-0002-9989-4053","position":6,"is_corresponding":false},{"id":910224,"name":"Mitchell T. Irwin","orcid":"0000-0003-2088-0028","position":7,"is_corresponding":false},{"id":910738,"name":"Johan Karlson","orcid":null,"position":8,"is_corresponding":false},{"id":910739,"name":"Andrew Perkin","orcid":null,"position":9,"is_corresponding":false},{"id":910225,"name":"Mrinalini Watsa","orcid":"0000-0002-8130-8810","position":10,"is_corresponding":false},{"id":910226,"name":"Gideon Erkenswick","orcid":"0000-0001-6040-1170","position":11,"is_corresponding":false},{"id":419968,"name":"Karen L. Bales","orcid":"0000-0001-5826-2095","position":12,"is_corresponding":false},{"id":726482,"name":"Dorothy L. Patton","orcid":null,"position":13,"is_corresponding":false},{"id":407387,"name":"Anna J. Jasinska","orcid":"0000-0002-1897-4570","position":14,"is_corresponding":false},{"id":844577,"name":"Eduardo Fernández‐Duque","orcid":"0000-0002-3993-7912","position":15,"is_corresponding":false},{"id":910227,"name":"Steven R. Leigh","orcid":"0000-0001-6844-7122","position":16,"is_corresponding":false},{"id":910228,"name":"Rebecca M. Stumpf","orcid":"0000-0002-4979-4994","position":17,"is_corresponding":false},{"id":910221,"name":"Abigail E. Asangba","orcid":"0000-0003-4223-6903","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:25:43.037820Z","pmid":"35587638","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}