{"doi":"10.1128/spectrum.01434-23","title":"Plasmodium falciparum GAP40 Plays an Essential Role in Merozoite Invasion and Gametocytogenesis","abstract":"Red blood cell invasion is central to the pathogenesis of the malaria parasite, and the parasite proteins involved in this process are potential therapeutic targets. Gliding motility powers merozoite invasion and is driven by a unique molecular motor termed the glideosome. The glideosome is stably anchored to the parasite inner membrane complex (IMC) through membrane-resident proteins. In the present study, we demonstrate the importance of an IMC-resident glideosome component, PfGAP40, that plays a critical role in stabilizing the expression levels of glideosome components in the schizont stage. We determined that phosphorylation of PfGAP40 at C-terminal residues is required for efficient merozoite invasion.","journal":"Microbiology Spectrum","year":2023,"id":353878,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334652,"name":"Yue Qiu","orcid":"0000-0001-7925-086X","position":1,"is_corresponding":false},{"id":1100981,"name":"Geping Pang","orcid":null,"position":2,"is_corresponding":false},{"id":889273,"name":"Siqi Li","orcid":"0000-0002-4569-1111","position":3,"is_corresponding":false},{"id":1100545,"name":"Jingjing Wang","orcid":"0000-0003-4383-2264","position":4,"is_corresponding":false},{"id":1100546,"name":"Yonghui Feng","orcid":"0000-0003-3145-6409","position":5,"is_corresponding":false},{"id":1100982,"name":"Lumeng Chen","orcid":null,"position":6,"is_corresponding":false},{"id":1100983,"name":"Liying Zhu","orcid":null,"position":7,"is_corresponding":false},{"id":1100984,"name":"Yinjie Liu","orcid":null,"position":8,"is_corresponding":false},{"id":308914,"name":"Liwang Cui","orcid":"0000-0002-8338-1974","position":9,"is_corresponding":false},{"id":334156,"name":"Yaming Cao","orcid":"0000-0001-5315-1636","position":10,"is_corresponding":false},{"id":436013,"name":"Xiaotong Zhu","orcid":"0000-0002-9064-586X","position":11,"is_corresponding":false},{"id":1100544,"name":"Lu He","orcid":"0000-0003-0149-0606","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T01:13:02.680107Z","pmid":"37249423","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}