{"doi":"10.1128/spectrum.01362-22","title":"Analysis of Intestinal Mycobiota of Patients with Clostridioides difficile Infection among a Prospective Inpatient Cohort","abstract":"Clostridioides difficile is an opportunistic bacterial pathogen that causes a serious and potentially life-threatening infection of the human gut. It remains an existing challenge to distinguish active infection of CDI from diarrhea with non-CDI causes. A few large prospective studies from recent years suggest that there is no single optimal test for the diagnosis of CDI. Previous research has concentrated on the relationship between bacteria and CDI, while the roles of fungi, as a significant proportion of the gut microbial ecosystem, remain understudied. In this study, we report a series of fungal markers that may add diagnostic values for the development of a more systematic approach to accurate CDI diagnosis. These results help open the door for better understanding of the relationship between host immune factors and the fungal community in the context of CDI pathogenesis.","journal":"Microbiology Spectrum","year":2022,"id":270275,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":684931,"name":"Lamei Wang","orcid":"0000-0002-0826-4268","position":1,"is_corresponding":false},{"id":580698,"name":"Shanlin Ke","orcid":"0000-0003-4101-0574","position":2,"is_corresponding":false},{"id":281003,"name":"Ciarán P. Kelly","orcid":"0000-0002-8216-1240","position":3,"is_corresponding":false},{"id":376971,"name":"Nira R. Pollock","orcid":"0000-0002-6396-2915","position":4,"is_corresponding":false},{"id":537919,"name":"Javier Villafuerte-Gálvez","orcid":"0000-0002-3379-5271","position":5,"is_corresponding":false},{"id":580699,"name":"Kaitlyn Daugherty","orcid":"0000-0002-3718-5585","position":6,"is_corresponding":false},{"id":406867,"name":"Hua Xu","orcid":"0000-0001-7510-2907","position":7,"is_corresponding":false},{"id":684934,"name":"Junhu Yao","orcid":"0000-0001-6318-6576","position":8,"is_corresponding":false},{"id":684935,"name":"Yulin Chen","orcid":"0000-0001-5679-4055","position":9,"is_corresponding":false},{"id":34346,"name":"Yang-Yu Liu","orcid":"0000-0003-2728-4907","position":10,"is_corresponding":false},{"id":406865,"name":"Xinhua Chen","orcid":"0000-0002-3944-3816","position":11,"is_corresponding":false},{"id":684930,"name":"Yangchun Cao","orcid":"0000-0003-1033-2909","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:27:26.772098Z","pmid":"35867408","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}