{"doi":"10.1128/spectrum.00928-21","title":"Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis","abstract":"essentiality and function of many of the protein-encoding genes expressed by M. tuberculosis are not known. We biochemically characterize M. tuberculosis's phosphopantetheinyl hydrolase, PptH, a protein unique to mycobacteria that removes an essential posttranslational modification on proteins involved in synthesis of lipids important for the bacterium's cell wall and virulence. We demonstrate that the enzyme has broad substrate specificity, but it does not appear to have a role in coenzyme A (CoA) salvage or virulence in a mouse model of TB.","journal":"Microbiology Spectrum","year":2021,"id":210008,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":798110,"name":"A.D. Singh","orcid":"0000-0001-5649-8483","position":1,"is_corresponding":false},{"id":671223,"name":"Guangli Yang","orcid":"0000-0002-5097-5266","position":2,"is_corresponding":false},{"id":798111,"name":"Felipe B. d’Andrea","orcid":"0000-0003-2265-4040","position":3,"is_corresponding":false},{"id":271239,"name":"Xiuju Jiang","orcid":"0000-0002-9965-8771","position":4,"is_corresponding":false},{"id":446863,"name":"Travis Hartman","orcid":"0000-0002-3926-6928","position":5,"is_corresponding":false},{"id":798112,"name":"John Mosior","orcid":"0000-0002-5649-7824","position":6,"is_corresponding":false},{"id":798113,"name":"Ronnie Bourland","orcid":"0000-0001-8239-3562","position":7,"is_corresponding":false},{"id":369604,"name":"Ben Gold","orcid":"0000-0002-9562-8241","position":8,"is_corresponding":false},{"id":369605,"name":"Julia Roberts","orcid":"0000-0002-9329-4671","position":9,"is_corresponding":false},{"id":309446,"name":"Annie Geiger","orcid":null,"position":10,"is_corresponding":false},{"id":798114,"name":"Su Tang","orcid":"0000-0002-6993-1212","position":11,"is_corresponding":false},{"id":293130,"name":"Kyu Y. Rhee","orcid":"0000-0003-4582-2895","position":12,"is_corresponding":false},{"id":335056,"name":"Ouathek Ouerfelli","orcid":"0000-0002-7038-0219","position":13,"is_corresponding":false},{"id":248998,"name":"James C. Sacchettini","orcid":"0000-0001-5767-2367","position":14,"is_corresponding":false},{"id":111358,"name":"Carl F. Nathan","orcid":"0000-0002-7744-8896","position":15,"is_corresponding":false},{"id":689528,"name":"Kristin Burns-Huang","orcid":"0000-0002-8202-3884","position":16,"is_corresponding":false},{"id":798601,"name":"Shilpika Pandey","orcid":null,"position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T23:52:08.869117Z","pmid":"34550010","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}