{"doi":"10.1128/spectrum.00647-23","title":"Identification of Fungus-Derived Natural Products as New Antigiardial Scaffolds","abstract":"There is a direct link between widespread prevalence of clinical giardiasis and poverty. This may be one of the reasons why giardiasis is a significant contributor to diarrheal morbidity, stunting, and death of children in resource-limited communities around the world. FDA-approved treatments for giardiasis include metronidazole, related nitroimidazole drugs, and albendazole. However, a substantial number of clinical infections are resistant to these treatments. The depth of the challenge is partly exacerbated by a lack of investment in the discovery and development of novel agents for treatment of giardiasis. Applicable interventions must include new drug development strategies that will result in the identification of effective therapeutics, particularly those that are inexpensive and can be quickly advanced to clinical uses, such as products from nature. This study identified novel chemical scaffolds from fungi that can form the basis of future medicinal chemistry optimization of novel antigiardial agents.","journal":"Microbiology Spectrum","year":2023,"id":386089,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":525639,"name":"Samantha A. Michaels","orcid":"0000-0002-3386-5233","position":1,"is_corresponding":false},{"id":1154385,"name":"Jin Woo Lee","orcid":"0000-0003-4245-9381","position":2,"is_corresponding":false},{"id":431631,"name":"Karen Wendt","orcid":"0000-0002-3532-043X","position":3,"is_corresponding":false},{"id":679607,"name":"Linh T. Tran","orcid":"0000-0002-9626-9439","position":4,"is_corresponding":false},{"id":352971,"name":"Ryan Choi","orcid":"0000-0001-9374-5893","position":5,"is_corresponding":false},{"id":352989,"name":"Wesley C. Van Voorhis","orcid":"0000-0001-6141-2015","position":6,"is_corresponding":false},{"id":422475,"name":"Robert H. Cichewicz","orcid":"0000-0003-0744-4117","position":7,"is_corresponding":false},{"id":352988,"name":"Kayode K. Ojo","orcid":"0000-0002-2007-2170","position":8,"is_corresponding":false},{"id":352972,"name":"Matthew A. Hulverson","orcid":"0000-0002-3413-4969","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:17:56.803401Z","pmid":"37039683","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}