{"doi":"10.1128/spectrum.00502-21","title":"Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin","abstract":"Antimicrobial resistance is an emerging global public health crisis, calling for urgent development of novel potent antibiotics. We propose that arsinothricin and related arsenic-containing compounds may be the progenitors of a new class of antibiotics to extend our antibiotic era. Here, we report identification of the biosynthetic gene cluster for arsinothricin and demonstrate that only three genes, two of which are novel, are required for the biosynthesis and transport of arsinothricin, in contrast to the phosphonate counterpart, phosphinothricin, which requires over 20 genes. Our discoveries will provide insight for the development of more effective organoarsenical antibiotics and illustrate the previously unknown complexity of the arsenic biogeochemical cycle, as well as bring new perspective to environmental arsenic biochemistry.","journal":"Microbiology Spectrum","year":2021,"id":160604,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":673837,"name":"Ngozi P. Paul","orcid":"0000-0003-0423-195X","position":1,"is_corresponding":false},{"id":267427,"name":"Jian Chen","orcid":"0000-0002-8508-675X","position":2,"is_corresponding":false},{"id":393126,"name":"Kunie Yoshinaga-Sakurai","orcid":"0009-0008-9785-0269","position":3,"is_corresponding":false},{"id":303986,"name":"Sagar M. Utturkar","orcid":"0000-0002-3453-1948","position":4,"is_corresponding":false},{"id":6560,"name":"Barry P. Rosen","orcid":"0000-0002-5230-4271","position":5,"is_corresponding":false},{"id":428978,"name":"Masahiro Yoshinaga","orcid":"0000-0002-7243-1761","position":6,"is_corresponding":false},{"id":673836,"name":"Adriana E. Galván","orcid":"0000-0002-2472-0438","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:44:48.240577Z","pmid":"34378964","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}