{"doi":"10.1128/spectrum.00340-23","title":"Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation <i>Ex Vivo</i> Model","abstract":"Our study supports the additional benefit of standard-of-care antibiotics combined with a phage cocktail compared to antibiotic alone against a daptomycin-nonsusceptible (DNS) E. faecium isolate in a high-inoculum simulated endocardial vegetation ex vivo PK/PD model. E. faecium is a leading cause of hospital-acquired infections and is associated with significant morbidity and mortality. Daptomycin is considered the first-line therapy for vancomycin-resistant E. faecium (VRE), but the highest published doses have failed to eradicate some VRE isolates.","journal":"Microbiology Spectrum","year":2023,"id":336349,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":373187,"name":"Kyle Stamper","orcid":null,"position":1,"is_corresponding":false},{"id":1032442,"name":"Amer El Ghali","orcid":"0000-0003-1744-0048","position":2,"is_corresponding":false},{"id":372458,"name":"Razieh Kebriaei","orcid":"0000-0003-4019-2679","position":3,"is_corresponding":false},{"id":239769,"name":"Biswajit Biswas","orcid":"0000-0002-3572-2068","position":4,"is_corresponding":false},{"id":598774,"name":"Melanie Wilson","orcid":"0009-0002-3901-4496","position":5,"is_corresponding":false},{"id":1067261,"name":"Michael V. Deschenes","orcid":null,"position":6,"is_corresponding":false},{"id":343887,"name":"Truc T. Tran","orcid":"0000-0002-2696-4196","position":7,"is_corresponding":false},{"id":232742,"name":"César A. Arias","orcid":"0000-0001-9054-9774","position":8,"is_corresponding":false},{"id":348336,"name":"Michael J. Rybak","orcid":"0000-0003-2220-0081","position":9,"is_corresponding":false},{"id":1032440,"name":"Ashlan J. Kunz Coyne","orcid":"0000-0002-4891-8625","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T01:10:17.243221Z","pmid":"37338375","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}