{"doi":"10.1128/spectrum.00016-21","title":"Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice","abstract":"Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is estimated to infect one-fourth of the world's population and is one of the leading causes of death due to an infectious disease worldwide. The high-level variability in tuberculosis disease responses in the human populace may be linked to immune processes related to inflammation. In many cases, inflammation appears to exasperate tuberculosis responses; however, some evidence suggests inflammatory processes improve control of M. tuberculosis infection. Here, we show an acute inflammatory stimulus in mice provides protection against M. tuberculosis for up to 6 months, suggesting acute inflammation can positively affect M. tuberculosis infection outcome.","journal":"Microbiology Spectrum","year":2021,"id":200244,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245271,"name":"Julia M. Scordo","orcid":"0000-0001-6571-6454","position":1,"is_corresponding":false},{"id":777444,"name":"Paula A. Pino","orcid":"0000-0001-8626-926X","position":2,"is_corresponding":false},{"id":245289,"name":"Larry S. Schlesinger","orcid":"0000-0002-7177-8421","position":3,"is_corresponding":false},{"id":245288,"name":"Jordi B. Torrelles","orcid":"0000-0001-7702-5941","position":4,"is_corresponding":false},{"id":245287,"name":"Joanne Turner","orcid":"0000-0002-0840-7484","position":5,"is_corresponding":false},{"id":588007,"name":"Tucker J. Piergallini","orcid":"0000-0002-3449-071X","position":0,"is_corresponding":true}],"reference_count":98,"raw_metadata":null,"created_at":"2026-07-18T23:50:44.479665Z","pmid":"34232086","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}