{"doi":"10.1128/spectrum.00002-22","title":"Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P","abstract":"hosphate (dhS1P), act as ligands for S1P receptors, and this interaction is known to play a central role in mediating angiogenesis, vascular stability and permeability, and immune cell migration to sites of inflammation. Studies suggest that a shift in ratio to higher levels of dhS1P in relation to S1P alters downstream signaling cascades due to differential binding and activation of the various S1P receptor isoforms. Specifically, higher levels of dhS1P are thought to be anti-inflammatory. Here, we report on the characterization of a novel kinase in Porphyromonas gingivalis that phosphorylates dihydrosphingosine to form dhS1P.","journal":"Microbiology Spectrum","year":2022,"id":273823,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9606,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":941809,"name":"Zachary D. Moye","orcid":null,"position":1,"is_corresponding":false},{"id":772521,"name":"Fernanda Regina Godoy Rocha","orcid":"0000-0002-3448-0562","position":2,"is_corresponding":false},{"id":475404,"name":"Gregory Ottenberg","orcid":"0000-0002-4402-7614","position":3,"is_corresponding":false},{"id":490135,"name":"Frank C. Nichols","orcid":"0000-0001-6800-1112","position":4,"is_corresponding":false},{"id":447166,"name":"Hey‐Min Kim","orcid":"0000-0003-3814-343X","position":5,"is_corresponding":false},{"id":344478,"name":"Alejandro R. Walker","orcid":"0000-0002-5839-6584","position":6,"is_corresponding":false},{"id":772523,"name":"Frank C. Gibson","orcid":"0000-0003-1988-1170","position":7,"is_corresponding":false},{"id":718941,"name":"Mary E. Davey","orcid":"0000-0001-8129-0537","position":8,"is_corresponding":false},{"id":763977,"name":"Dev K. Ranjit","orcid":null,"position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T00:28:03.504676Z","pmid":"35286133","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}