{"doi":"10.1128/msystems.01209-20","title":"Mitochondrion-Dependent Apoptosis Is Essential for Rickettsia parkeri Infection and Replication in Vector Cells","abstract":"spp., vertebrate hosts, and arthropod vectors. Here, we demonstrated that mitochondrion-dependent apoptosis is essential for rickettsial infection and replication in vector cells and that apoptosis induction requires intracellular rickettsial replication. However, rickettsial pathogenicity is not linked with apoptosis activation in tick cells. Our findings improve understanding of the apoptosis mechanism in arthropods exploited by rickettsiae and also the potential to discover specific targets for new vaccines and drugs to prevent or treat rickettsial infections.","journal":"mSystems","year":2021,"id":190713,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9631,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":306450,"name":"Nicole Y. Burkhardt","orcid":null,"position":1,"is_corresponding":false},{"id":304870,"name":"Timothy J. Kurtti","orcid":"0000-0002-7935-2249","position":2,"is_corresponding":false},{"id":304868,"name":"Jonathan D. Oliver","orcid":"0000-0002-8738-112X","position":3,"is_corresponding":false},{"id":306449,"name":"Lisa D. Price","orcid":null,"position":4,"is_corresponding":false},{"id":718367,"name":"Benjamin Cull","orcid":"0000-0001-6814-5669","position":5,"is_corresponding":false},{"id":306451,"name":"Cody J. Thorpe","orcid":null,"position":6,"is_corresponding":false},{"id":755546,"name":"Michalina Silva Thiel","orcid":null,"position":7,"is_corresponding":false},{"id":304871,"name":"Ulrike G. Munderloh","orcid":"0000-0001-7935-2874","position":8,"is_corresponding":false},{"id":361477,"name":"Xin-Ru Wang","orcid":"0000-0002-9692-865X","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-18T23:49:26.966524Z","pmid":"33727398","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}