{"doi":"10.1128/msystems.00872-20","title":"Manipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector Pair","abstract":"to maintain survival in the environment, whereas the second system, T3SS2, is linked to clinical isolates and disease in humans. Here, we found that first system targets evolutionarily conserved signaling systems to manipulate host cells, eventually causing a rapid, orchestrated cells death within 3 h. We have found that the T3SS1 injects virulence factors that temporally manipulate host signaling. Within the first hour of infection, the effector VopQ acts first by activating host survival signals while diminishing the host cell apoptotic machinery. Less than an hour later, another effector, VopS, reverses activation and inhibition of these signaling systems, ultimately leading to death of the host cell. This work provides example of how pathogens have evolved to manipulate the interplay between T3SS effectors to regulate host signaling pathways.","journal":"mSystems","year":2021,"id":199725,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":567710,"name":"Amanda K. Casey","orcid":"0000-0002-5829-748X","position":1,"is_corresponding":false},{"id":240349,"name":"Mohammed Kanchwala","orcid":"0000-0001-6035-2970","position":2,"is_corresponding":false},{"id":495051,"name":"Alexander E. Lafrance","orcid":null,"position":3,"is_corresponding":false},{"id":454858,"name":"Fatma S. Coskun","orcid":"0000-0001-5537-0867","position":4,"is_corresponding":false},{"id":233715,"name":"Lisa N. Kinch","orcid":"0000-0003-3041-2615","position":5,"is_corresponding":false},{"id":396818,"name":"Nick V. Grishin","orcid":"0000-0003-4108-1153","position":6,"is_corresponding":false},{"id":240348,"name":"Chao Xing","orcid":"0000-0002-1838-0502","position":7,"is_corresponding":false},{"id":488376,"name":"Kim Orth","orcid":"0000-0002-0678-7620","position":8,"is_corresponding":false},{"id":567709,"name":"Nicole J. De Nisco","orcid":"0000-0002-7670-5301","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T23:50:40.558460Z","pmid":"33563785","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}