{"doi":"10.1128/msystems.00765-19","title":"A High-Fat/High-Protein, Atkins-Type Diet Exacerbates <i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> Infection in Mice, whereas a High-Carbohydrate Diet Protects","abstract":"The role of Western and weight-loss diets with extreme macronutrient composition in the risk and progression of CDI is poorly understood. In a longitudinal study, we showed that a high-fat/high-protein, Atkins-type diet greatly exacerbated antibiotic-induced CDI, whereas a high-carbohydrate diet protected, despite the high monosaccharide and starch content. Our study results, therefore, suggest that popular high-fat/high-protein weight-loss diets may enhance CDI risk during antibiotic treatment, possibly due to the synergistic effects of a loss of the microorganisms that normally inhibit C. difficile overgrowth and an abundance of amino acids that promote C. difficile overgrowth. In contrast, a high-carbohydrate diet might be protective, despite reports on the recent evolution of enhanced carbohydrate metabolism in C. difficile .","journal":"mSystems","year":2020,"id":56154,"datarank":0.6716005221717312,"base_score":4.477336814478207,"endowment":4.477336814478207,"self_citation_contribution":0.6716005221717312,"citation_network_contribution":0.0,"self_endowment_contribution":0.6716005221717312,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":87,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":291639,"name":"Shrikant S. Bhute","orcid":"0000-0003-1576-3548","position":1,"is_corresponding":false},{"id":291640,"name":"Jacqueline R. Phan","orcid":"0000-0002-5689-6462","position":2,"is_corresponding":false},{"id":293504,"name":"Jacob V. Villarama","orcid":null,"position":3,"is_corresponding":false},{"id":293505,"name":"M. Dung","orcid":null,"position":4,"is_corresponding":false},{"id":293506,"name":"Stephanie Alarcia","orcid":null,"position":5,"is_corresponding":false},{"id":291641,"name":"Ernesto Abel‐Santos","orcid":"0000-0002-2628-9493","position":6,"is_corresponding":false},{"id":291642,"name":"Brian P. Hedlund","orcid":"0000-0001-8530-0448","position":7,"is_corresponding":false},{"id":293503,"name":"Chrisabelle C. Mefferd","orcid":null,"position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:05:49.581291Z","pmid":"32047064","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}