{"doi":"10.1128/msystems.00710-22","title":"Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions","abstract":"As the world becomes increasingly industrialized, understanding the biological consequences of these lifestyle shifts and what it means for past, present, and future human health is critical. Indeed, industrialization is associated with rises in allergic and autoimmune health conditions and reduced microbial diversity. Exploring these health effects on a chemical level requires consideration of human lifestyle diversity, but understanding the significance of any differences also requires knowledge of what molecular components are shared between human groups. Our study reveals the key chemistry of the human gut as defined by varied industrialization-based differences and ubiquitous shared features. Ultimately, these novel findings extend our knowledge of human molecular biology, especially as it is influenced by lifestyle and behavior, and provide steps toward understanding how human biology has changed over our species' history.","journal":"mSystems","year":2022,"id":281812,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342919,"name":"Mitchelle Katemauswa","orcid":"0000-0001-9624-8737","position":1,"is_corresponding":false},{"id":327633,"name":"Thérèse Kagone","orcid":null,"position":2,"is_corresponding":false},{"id":342911,"name":"Ekram Hossain","orcid":"0000-0002-0616-3420","position":3,"is_corresponding":false},{"id":327634,"name":"David Jacobson","orcid":null,"position":4,"is_corresponding":false},{"id":342918,"name":"Karina Flores","orcid":"0000-0001-8212-8873","position":5,"is_corresponding":false},{"id":342917,"name":"Adwaita R. Parab","orcid":"0000-0001-9523-8908","position":6,"is_corresponding":false},{"id":744488,"name":"Alexandra J. Obregón-Tito","orcid":"0000-0003-2508-7176","position":7,"is_corresponding":false},{"id":744487,"name":"Raúl Y. Tito","orcid":"0000-0001-9660-7621","position":8,"is_corresponding":false},{"id":745309,"name":"Luis Marín Reyes","orcid":null,"position":9,"is_corresponding":false},{"id":744489,"name":"Luzmila Troncoso-Corzo","orcid":"0000-0003-1075-874X","position":10,"is_corresponding":false},{"id":744490,"name":"Emilio Guija-Poma","orcid":"0000-0002-2522-2772","position":11,"is_corresponding":false},{"id":326194,"name":"Nicolas Méda","orcid":"0000-0003-2523-8747","position":12,"is_corresponding":false},{"id":326195,"name":"Hélène Carabin","orcid":"0000-0002-2822-4730","position":13,"is_corresponding":false},{"id":326186,"name":"Tanvi P. Honap","orcid":"0000-0001-5271-9162","position":14,"is_corresponding":false},{"id":342871,"name":"Krithivasan Sankaranarayanan","orcid":"0000-0002-4767-311X","position":15,"is_corresponding":false},{"id":29118,"name":"Cecil M. Lewis","orcid":"0000-0002-2198-3427","position":16,"is_corresponding":false},{"id":105872,"name":"Laura‐Isobel McCall","orcid":"0000-0002-1243-8953","position":17,"is_corresponding":false},{"id":886305,"name":"Jacob J. Haffner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":null,"created_at":"2026-07-19T00:29:11.698554Z","pmid":"36416540","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}