{"doi":"10.1128/msystems.00381-21","title":"Assessing the Impact of Flavophospholipol and Virginiamycin Supplementation on the Broiler Microbiota: a Prospective Controlled Intervention Study","abstract":"Antibiotic growth promoters (AGPs) are commonly used within poultry farming to increase muscle growth. Microbial composition in the gut is known to be influenced by AGP use although exact AGP-induced changes remain unclear. Utilizing 16S rRNA gene profiling, this study provides a first head-to-head comparison of the effect of the two most commonly used AGPs, flavophospholipol and virginiamycin, on the broiler chicken ileum microbiota over time. We found that supplementation with both AGPs altered ileal microbial composition, thereby increasing potential bioavailability of essential nutrients and weight gain. Flavophospholipol showed a slight benefit over virginiamycin as the latter resulted in more extensive microbial perturbations including increased colonization by enteropathogens, which could impact broiler mortality.","journal":"mSystems","year":2021,"id":206911,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":640805,"name":"Matilda Berkell","orcid":"0000-0002-7096-7896","position":1,"is_corresponding":false},{"id":640807,"name":"Basil Britto Xavier","orcid":"0000-0002-5897-0240","position":2,"is_corresponding":false},{"id":791895,"name":"Sarah De Backer","orcid":"0000-0002-6488-1893","position":3,"is_corresponding":false},{"id":640810,"name":"Christine Lammens","orcid":"0000-0001-9424-3107","position":4,"is_corresponding":false},{"id":792487,"name":"Veerle Hautekiet","orcid":null,"position":5,"is_corresponding":false},{"id":792488,"name":"S. Petkov","orcid":null,"position":6,"is_corresponding":false},{"id":640812,"name":"Herman Goossens","orcid":"0000-0003-4891-4031","position":7,"is_corresponding":false},{"id":791896,"name":"Samir Kumar‐Singh","orcid":"0000-0001-9466-6732","position":8,"is_corresponding":false},{"id":640814,"name":"Surbhi Malhotra‐Kumar","orcid":"0000-0001-8699-8905","position":9,"is_corresponding":false},{"id":640806,"name":"Mohamed Mysara","orcid":"0000-0001-5746-4330","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-18T23:51:45.688025Z","pmid":"34463581","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}