{"doi":"10.1128/msystems.00368-20","title":"Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B<i>Streptococcus</i>","abstract":"(GBS) meningitis remains a major cause of poor health outcomes very early in life. Both the host-pathogen relationship leading to disease and the massive host response to infection contributing to these poor outcomes are orchestrated at the tissue and cell type levels. GBS meningitis is thought to result when bacteria present in the blood circumvent the selectively permeable vascular barriers that feed the brain. Additionally, tissue damage subsequent to bacterial invasion is mediated by inflammation and by immune cells from the periphery crossing the blood-brain barrier. Indeed, the vasculature plays a central role in disease processes occurring during GBS infection of the brain. Here, we employed quantitative proteomic analysis of brain vascular substructures during invasive GBS disease. We used the generated data to map molecular alterations associated with tissue perturbation, finding widespread intracellular dysfunction and punctuating the importance of investigations relegated to tissue type over the whole organ.","journal":"mSystems","year":2020,"id":83615,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270144,"name":"Robert H. Mills","orcid":"0000-0002-0749-9524","position":1,"is_corresponding":false},{"id":430144,"name":"Marie Blanchette","orcid":"0000-0003-1187-8700","position":2,"is_corresponding":false},{"id":431212,"name":"Kaja Bajc","orcid":null,"position":3,"is_corresponding":false},{"id":430145,"name":"Mario Malfavon","orcid":"0000-0002-0180-4006","position":4,"is_corresponding":false},{"id":430146,"name":"Roeben N. Munji","orcid":"0000-0003-1313-8968","position":5,"is_corresponding":false},{"id":351250,"name":"Liwen Deng","orcid":"0000-0002-7984-8471","position":6,"is_corresponding":false},{"id":431213,"name":"Bryan Hancock","orcid":null,"position":7,"is_corresponding":false},{"id":225239,"name":"Kathryn A. Patras","orcid":"0000-0003-2631-8810","position":8,"is_corresponding":false},{"id":270145,"name":"Joshua Olson","orcid":"0000-0002-1733-0431","position":9,"is_corresponding":false},{"id":225262,"name":"Victor Nizet","orcid":"0000-0003-3847-0422","position":10,"is_corresponding":false},{"id":430147,"name":"Richard Daneman","orcid":"0000-0002-7749-6353","position":11,"is_corresponding":false},{"id":351256,"name":"Kelly S. Doran","orcid":"0000-0003-4232-6837","position":12,"is_corresponding":false},{"id":270151,"name":"David J. Gonzalez","orcid":"0000-0003-1423-5970","position":13,"is_corresponding":false},{"id":430143,"name":"Anaamika Campeau","orcid":"0000-0002-0241-8908","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T21:54:32.422022Z","pmid":"32843537","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}