{"doi":"10.1128/msystems.00329-20","title":"Selective Translation of Low Abundance and Upregulated Transcripts in Halobacterium salinarum","abstract":"Our findings demonstrate conclusively that low abundance and upregulated transcripts are preferentially translated, potentially by environment-specific translation systems with distinct ribosomal protein composition. We show that a complex interplay of transcriptional and posttranscriptional regulation underlies the conditional and modular regulatory programs that generate ribosomes of distinct protein composition. The modular regulation of ribosomal proteins with other transcription, translation, and metabolic genes is generalizable to bacterial and eukaryotic microbes. These findings are relevant to how microorganisms adapt to unfavorable environments when they transition from active growth to quiescence by generating proteins from upregulated transcripts that are in considerably lower abundance relative to transcripts associated with the previous physiological state. Selective translation of transcripts by distinct ribosomes could form the basis for adaptive evolution to new environments through a modular regulation of the translational systems.","journal":"mSystems","year":2020,"id":86578,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":148312,"name":"Ulrike Kusebauch","orcid":"0000-0001-6162-7577","position":1,"is_corresponding":false},{"id":442648,"name":"Arjun V. Raman","orcid":null,"position":2,"is_corresponding":false},{"id":441560,"name":"Min Pan","orcid":"0000-0002-9781-0637","position":3,"is_corresponding":false},{"id":441561,"name":"Serdar Turkarslan","orcid":"0000-0003-1679-6405","position":4,"is_corresponding":false},{"id":441562,"name":"Alan P. R. Lorenzetti","orcid":"0000-0002-0291-248X","position":5,"is_corresponding":false},{"id":78845,"name":"Robert L. Moritz","orcid":"0000-0002-3216-9447","position":6,"is_corresponding":false},{"id":400246,"name":"Nitin S. Baliga","orcid":"0000-0001-9157-5974","position":7,"is_corresponding":false},{"id":441559,"name":"Adrián López García de Lomana","orcid":"0000-0002-9748-347X","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32723790","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}