{"doi":"10.1128/msystems.00065-20","title":"Subspecies Niche Specialization in the Oral Microbiome Is Associated with Nasopharyngeal Carcinoma Risk","abstract":"The relationship between oral health and the risk of nasopharyngeal carcinoma (NPC) was previously established. However, the role of oral microbiome has not been evaluated in the disease in a large epidemiological study. This paper clearly establishes a difference in the oral microbiomes between NPC patients and healthy controls which cannot be explained by other confounding factors. It furthermore identifies a pair of closely related coexcluding organisms associated with the disease, highlighting the importance of modern methods for single-nucleotide resolution in 16S rRNA sequence characterization. To the best of our knowledge, this is one of the first examples of cancer-associated niche specialization of the oral microbiome.","journal":"mSystems","year":2020,"id":98564,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":386038,"name":"Tingting Huang","orcid":"0000-0003-2314-4448","position":1,"is_corresponding":false},{"id":386031,"name":"Yonglin Cai","orcid":"0000-0002-2001-1351","position":2,"is_corresponding":false},{"id":228605,"name":"Alexander Ploner","orcid":"0000-0002-5042-8326","position":3,"is_corresponding":false},{"id":486295,"name":"Donal Barrett","orcid":"0000-0001-5381-5391","position":4,"is_corresponding":false},{"id":486296,"name":"Xiaoying Zhou","orcid":"0000-0003-3298-5089","position":5,"is_corresponding":false},{"id":486297,"name":"Xue Xiao","orcid":"0000-0003-1384-9954","position":6,"is_corresponding":false},{"id":486298,"name":"Yancheng Li","orcid":"0000-0002-0849-4194","position":7,"is_corresponding":false},{"id":386036,"name":"Jian Liao","orcid":"0000-0003-3519-4485","position":8,"is_corresponding":false},{"id":386794,"name":"Yuming Zheng","orcid":null,"position":9,"is_corresponding":false},{"id":486299,"name":"Guangwu Huang","orcid":"0000-0002-7376-5691","position":10,"is_corresponding":false},{"id":35962,"name":"Hans‐Olov Adami","orcid":"0000-0001-9592-5791","position":11,"is_corresponding":false},{"id":486300,"name":"Yi Zeng","orcid":"0000-0002-1357-7998","position":12,"is_corresponding":false},{"id":386032,"name":"Zhe Zhang","orcid":"0000-0001-8816-3194","position":13,"is_corresponding":false},{"id":386042,"name":"Weimin Ye","orcid":"0000-0002-6859-4648","position":14,"is_corresponding":false},{"id":228769,"name":"Justine W. Debelius","orcid":"0000-0002-8605-3546","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-18T22:36:58.511143Z","pmid":"32636333","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}