{"doi":"10.1128/msphere.00852-20","title":"Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota","abstract":"Staphylococcus aureus and Streptococcus pneumoniae infections cause significant morbidity and mortality in humans. For both, nasal colonization is a risk factor for infection. Studies of nasal microbiota identify Dolosigranulum pigrum as a benign bacterium present when adults are free of S. aureus or when children are free of S. pneumoniae . Here, we validated these in vivo associations with functional assays. We found that D. pigrum inhibited S. aureus in vitro and, together with a specific nasal Corynebacterium species, also inhibited S. pneumoniae . Furthermore, genomic analysis of D. pigrum indicated that it must obtain key nutrients from other nasal bacteria or from humans. These phenotypic interactions support the idea of a role for microbe-microbe interactions in shaping the composition of human nasal microbiota and implicate D. pigrum as a mutualist of humans. These findings support the feasibility of future development of microbe-targeted interventions to reshape nasal microbiota composition to exclude S. aureus and/or S. pneumoniae .","journal":"mSphere","year":2020,"id":51523,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":154,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9653,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256346,"name":"Sara M. Eslami","orcid":"0000-0003-3397-0583","position":1,"is_corresponding":false},{"id":257769,"name":"Melinda M. Pettigrew","orcid":"0000-0001-8145-7536","position":2,"is_corresponding":false},{"id":257770,"name":"Isabel F. Escapa","orcid":"0000-0002-1454-7205","position":3,"is_corresponding":false},{"id":257771,"name":"Matthew T. Henke","orcid":"0000-0001-8325-6420","position":4,"is_corresponding":false},{"id":51180,"name":"Yong Kong","orcid":"0000-0002-2881-5274","position":5,"is_corresponding":false},{"id":29116,"name":"Katherine P. Lemon","orcid":"0000-0003-1542-1679","position":6,"is_corresponding":false},{"id":257768,"name":"Silvio D. Brugger","orcid":"0000-0001-9492-9088","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":null,"created_at":"2026-07-18T20:41:30.009880Z","pmid":"32907957","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}