{"doi":"10.1128/msphere.00826-19","title":"Herpes Simplex Virus Glycoprotein C Regulates Low-pH Entry","abstract":"Herpesviruses are ubiquitous pathogens that cause lifelong latent infections and that are characterized by multiple entry pathways. We propose that herpes simplex virus (HSV) gC plays a selective role in modulating HSV entry, such as entry into epithelial cells, by a low-pH pathway. gC facilitates a conformational change of the main fusogen gB, a class III fusion protein. We propose a model whereby gC functions with gB, gD, and gH/gL to allow low-pH entry. In the absence of gC, HSV entry occurs at a lower pH, coincident with trafficking to a lower pH compartment where gB changes occur at more acidic pHs. This report identifies a new function for gC and provides novel insight into the complex mechanism of HSV entry and fusion.","journal":"mSphere","year":2020,"id":101291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":495994,"name":"Katrina A. Gianopulos","orcid":"0000-0001-9395-7335","position":1,"is_corresponding":false},{"id":495995,"name":"Darin J. Weed","orcid":"0000-0002-5432-8074","position":2,"is_corresponding":false},{"id":496771,"name":"Seth M. Schneider","orcid":null,"position":3,"is_corresponding":false},{"id":487625,"name":"Suzanne M. Pritchard","orcid":null,"position":4,"is_corresponding":false},{"id":486687,"name":"Anthony V. Nicola","orcid":"0000-0001-8757-0417","position":5,"is_corresponding":false},{"id":495993,"name":"Tri Komala Sari","orcid":"0000-0002-7801-474X","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-18T22:39:38.259162Z","pmid":"32024702","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}