{"doi":"10.1128/msphere.00500-20","title":"The Agr-Like Quorum-Sensing System Is Important for <i>Clostridium perfringens</i> Type A Strain ATCC 3624 To Cause Gas Gangrene in a Mouse Model","abstract":"Clostridium perfringens type A strains produce toxins that are responsible for clostridial myonecrosis, also known as gas gangrene. Toxin production is regulated by an Agr-like quorum-sensing (QS) system that responds to changes in cell population density. In this study, we investigated the importance of this QS system in a mouse model of gas gangrene. Mice challenged with a C. perfringens strain with a nonfunctional regulatory system developed less severe changes in the injected skeletal muscle compared to animals receiving the wild-type strain. In addition, a synthetic peptide was able to decrease the effects of the QS in this disease model. These studies provide new understanding of the pathogenesis of gas gangrene and identified a potential therapeutic target to prevent the disease.","journal":"mSphere","year":2020,"id":71582,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":378309,"name":"Jihong Li","orcid":"0000-0002-5162-2737","position":1,"is_corresponding":false},{"id":379717,"name":"Juliann Beingesser","orcid":null,"position":2,"is_corresponding":false},{"id":378310,"name":"Bruce A. McClane","orcid":"0000-0003-2451-5140","position":3,"is_corresponding":false},{"id":378311,"name":"Francisco A. Uzal","orcid":"0000-0003-0681-1878","position":4,"is_corresponding":false},{"id":378308,"name":"Mauricio A. Navarro","orcid":"0000-0002-7744-8052","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T21:44:25.469842Z","pmid":"32554714","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}