{"doi":"10.1128/msphere.00439-22","title":"The Short-chain Fatty Acid Propionic Acid Activates the Rcs Stress Response System Partially through Inhibition of <scp>d-</scp> Alanine Racemase","abstract":"The Rcs bacterial stress response system responds to envelope stresses by globally altering gene expression to profoundly impact host-pathogen interactions, virulence, and antibiotic tolerance. In this study, a luminescent Rcs-reporter plasmid was used to screen a library of compounds for activators of Rcs. Among the strongest inducers was the short-chain fatty acid propionic acid, which is found at high concentrations in the human gut. This study suggests that gut short-chain fatty acids can affect both bacterial virulence and antibiotic tolerance via the induction of the Rcs system.","journal":"mSphere","year":2023,"id":366681,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":990826,"name":"Mitchell Meyer","orcid":"0000-0001-6058-0738","position":1,"is_corresponding":false},{"id":450899,"name":"Nicholas A. Stella","orcid":"0000-0002-6591-6912","position":2,"is_corresponding":false},{"id":452033,"name":"Kara M. Lehner","orcid":null,"position":3,"is_corresponding":false},{"id":699394,"name":"Regis P. Kowalski","orcid":"0000-0002-8558-0782","position":4,"is_corresponding":false},{"id":425714,"name":"Robert M. Q. Shanks","orcid":"0000-0002-7699-5396","position":5,"is_corresponding":false},{"id":991386,"name":"Nathaniel S. Harshaw","orcid":null,"position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T01:14:59.372548Z","pmid":"36645277","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}