{"doi":"10.1128/msphere.00429-20","title":"Systematic Review and Meta-analysis of the Prevalence of Group A Streptococcal <i>emm</i> Clusters in Africa To Inform Vaccine Development","abstract":"Low vaccine coverage is of grave public health concern, particularly in developing countries where epidemiological data are often absent. To inform vaccine development for group A Streptococcus (GAS), we report on the epidemiology of the M protein emm clusters from GAS infections in Africa, where GAS-related illnesses and their sequelae, including rheumatic fever and rheumatic heart disease, are of a high burden. This first report of emm clusters across the continent indicates a high probably of coverage by the M protein-based vaccine currently undergoing testing were an emm -cluster based approach to be used.","journal":"mSphere","year":2020,"id":78075,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9625,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":407983,"name":"Kélin Engel","orcid":null,"position":1,"is_corresponding":false},{"id":407984,"name":"Annesinah Moloi","orcid":null,"position":2,"is_corresponding":false},{"id":406545,"name":"Babu Muhamed","orcid":"0000-0003-4832-0671","position":3,"is_corresponding":false},{"id":406546,"name":"James B. Dale","orcid":"0000-0001-9860-9233","position":4,"is_corresponding":false},{"id":406547,"name":"Mark E. Engel","orcid":"0000-0002-1334-8829","position":5,"is_corresponding":false},{"id":407982,"name":"Taariq Salie","orcid":null,"position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T21:49:40.769098Z","pmid":"32669471","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}