{"doi":"10.1128/msphere.00310-22","title":"Defining the HIV Capsid Binding Site of Nucleoporin 153","abstract":"The human immunodeficiency virus (HIV) can infect nondividing cells by interacting with the host nuclear pore complex. The host nuclear pore protein NUP153 directly interacts with the HIV capsid to promote viral nuclear entry. This study used a multidisciplinary approach combining computational and experimental techniques to comprehensively map the effect of mutating the amino acids of NUP153 on HIV capsid interaction. This work showed a significant correlation between computational and empirical data sets, revealing that the HIV capsid interacted specifically with only six amino acids of NUP153. The simplicity of the interaction motif suggested other FG-containing motifs could also interact with the HIV-1 capsid. Furthermore, it was predicted that naturally occurring polymorphisms in human and nonhuman primates would disrupt NUP153 interaction with capsid, potentially protecting certain populations from HIV-1 infection.","journal":"mSphere","year":2022,"id":282625,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371516,"name":"Jagdish Suresh Patel","orcid":"0000-0003-4999-5347","position":1,"is_corresponding":false},{"id":486114,"name":"Jordan Yang","orcid":"0000-0001-8679-4347","position":2,"is_corresponding":false},{"id":424083,"name":"Angela Crabtree","orcid":"0000-0001-6584-8158","position":3,"is_corresponding":false},{"id":486119,"name":"Brenda M. Rubenstein","orcid":"0000-0003-1643-0358","position":4,"is_corresponding":false},{"id":807448,"name":"Peik K. Lund-Andersen","orcid":null,"position":5,"is_corresponding":false},{"id":371517,"name":"F. Marty Ytreberg","orcid":"0000-0001-7439-8224","position":6,"is_corresponding":false},{"id":424085,"name":"Paul A. Rowley","orcid":"0000-0002-3590-5139","position":7,"is_corresponding":false},{"id":584824,"name":"Shunji Li","orcid":"0000-0003-1695-4899","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T00:29:19.691592Z","pmid":"36040047","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}