{"doi":"10.1128/msphere.00238-20","title":"Alternating Dynamics of\n                    <i>oriC</i>\n                    , SMC, and MksBEF in Segregation of Pseudomonas aeruginosa Chromosome","abstract":"<jats:p>\n                    Mechanisms that define the chromosome as a structural entity remain unknown. Key elements in this process are condensins, which globally organize chromosomes and contribute to their segregation. This study characterized condensin and chromosome dynamics in\n                    <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa</jats:named-content>\n                    , which harbors condensins from two major protein superfamilies, SMC and MksBEF. The study revealed that both proteins play a dual role in chromosome maintenance by spatially organizing the chromosomes and guiding their segregation but can substitute for each other in some activities. The timing of chromosome, SMC, and MksBEF relocation was highly ordered and interdependent, revealing causative relationships in the process. Moreover, MksBEF produced clusters at the site of chromosome replication that survived cell division and remained in place until replication was complete. Overall, these data delineate the functions of condensins from the SMC and MksBEF superfamilies, reveal the existence of a chromosome organizing center, and suggest a mechanism that might explain the biogenesis of chromosomes.\n                  </jats:p>","journal":"mSphere","year":2020,"id":662601,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":581358,"name":"Bijit K. Bhowmik","orcid":"0000-0001-5141-7461","position":1,"is_corresponding":false},{"id":1729817,"name":"Zoya M. Petrushenko","orcid":null,"position":2,"is_corresponding":false},{"id":581359,"name":"Valentin V. Rybenkov","orcid":"0000-0002-5300-4369","position":3,"is_corresponding":false},{"id":960479,"name":"Hang Zhao","orcid":"0000-0003-4281-673X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Alternating Dynamics of\n                    <i>oriC</i>\n                    , SMC, and MksBEF in Segregation of Pseudomonas aeruginosa Chromosome","abstract":"<jats:p>\n                    Mechanisms that define the chromosome as a structural entity remain unknown. Key elements in this process are condensins, which globally organize chromosomes and contribute to their segregation. This study characterized condensin and chromosome dynamics in\n                    <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa</jats:named-content>\n                    , which harbors condensins from two major protein superfamilies, SMC and MksBEF. The study revealed that both proteins play a dual role in chromosome maintenance by spatially organizing the chromosomes and guiding their segregation but can substitute for each other in some activities. The timing of chromosome, SMC, and MksBEF relocation was highly ordered and interdependent, revealing causative relationships in the process. Moreover, MksBEF produced clusters at the site of chromosome replication that survived cell division and remained in place until replication was complete. Overall, these data delineate the functions of condensins from the SMC and MksBEF superfamilies, reveal the existence of a chromosome organizing center, and suggest a mechanism that might explain the biogenesis of chromosomes.\n                  </jats:p>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32907947","pmcid":"PMC7485682","openalex_id":"https://openalex.org/W3085894733","authors":[],"funders":[{"funder_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","grant_id":"AI141927","title":null},{"funder_name":"HHS | NIH | National Eye Institute","grant_id":"EY029015","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R21 EY029015","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI141927","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21AI141927-01A1","title":"Small molecule inhibitors of bacterial condensins"},{"funder_name":"National Institutes of Health","grant_id":"1R21EY029015-01","title":"Novel Antimicrobials for Eye Infections"}],"total_grants":6,"fwci":1.123,"citation_percentile":0.79144277,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1128/msphere.00238-20","host_type":"journal"},{"url":"https://doi.org/10.1128/msphere.00238-20","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/mSphere.00238-20","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32907947","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7485682","host_type":"repository"},{"url":"https://doaj.org/article/8dec6d2ab33142a4983c6b6a6c3734ff","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7485682","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7485682?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1128/mSphere.00238-20","host_type":""},{"url":"https://dx.doi.org/10.1128/msphere.00238-20","host_type":""}],"fields_of_study":["Bacterial Genetics and Biotechnology","Bacterial biofilms and quorum sensing","Bacteriophages and microbial interactions","0301 basic medicine","0303 health sciences","03 medical and health sciences","Adenosine Triphosphatases","Bacterial Proteins","Cell Cycle Proteins","Chromosome Segregation","Chromosomes, Bacterial","DNA, Bacterial","DNA-Binding Proteins","Multiprotein Complexes","Origin Recognition Complex","Pseudomonas aeruginosa"],"mesh_terms":["Adenosine Triphosphatases","Bacterial Proteins","Chromosomes, Bacterial","DNA-Binding Proteins","DNA, Bacterial","Pseudomonas aeruginosa","Cell Cycle Proteins","Chromosome Segregation","Multiprotein Complexes","Origin Recognition Complex"],"keywords":["Condensin","Chromosome segregation","Chromosome","Biology","Genetics","Pseudomonas aeruginosa","Bacteria","Gene","SMC","Condensins","Chromosome Structure","Smc Proteins","Mksbef","Mksb","Adenosine Triphosphatases","DNA, Bacterial","Origin Recognition Complex","Cell Cycle Proteins","Chromosomes, Bacterial","Microbiology","QR1-502","DNA-Binding Proteins","Bacterial Proteins","Multiprotein Complexes","Research Article"],"sdg_mappings":[{"sdg_number":16,"sdg_label":"16. 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