{"doi":"10.1128/msphere.00120-20","title":"Vaccine Candidate Brucella melitensis 16M <i>ΔvjbR</i> Is Safe in a Pregnant Sheep Model and Confers Protection","abstract":"Brucellosis is one of the most commonly reported zoonotic disease with a worldwide distribution. Of the 12 Brucella species, Brucella melitensis is considered the most virulent and causes reproductive failure (abortions/stillbirths) in small ruminants, which can spread the disease to other animals or to humans. Vaccination of small ruminants is a key measure used to protect both human and animal health. However, the commercially available live-attenuated vaccine for Brucella melitensis Rev. 1 retains virulence and can cause disease in animals and humans. In order to evaluate the safety and efficacy in sheep, we vaccinated pregnant sheep with 16M ΔvjbR . Our results indicate that 16M ΔvjbR was safer for use during pregnancy, provided a similar level of protection as Rev. 1, and could be considered an improved candidate for future vaccine trials.","journal":"mSphere","year":2020,"id":68342,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361962,"name":"Daniel García González","orcid":"0000-0002-9566-308X","position":1,"is_corresponding":false},{"id":361963,"name":"Sankar P. Chaki","orcid":"0000-0002-8130-6997","position":2,"is_corresponding":false},{"id":228128,"name":"Airn E. Hartwig","orcid":"0000-0003-4830-8074","position":3,"is_corresponding":false},{"id":228130,"name":"Paul Gordy","orcid":"0000-0002-9430-7622","position":4,"is_corresponding":false},{"id":228136,"name":"Richard A. Bowen","orcid":"0000-0002-7576-2881","position":5,"is_corresponding":false},{"id":361964,"name":"Thomas A. Ficht","orcid":"0000-0003-3311-1906","position":6,"is_corresponding":false},{"id":261761,"name":"Ángela M. Arenas-Gamboa","orcid":"0000-0002-1631-2653","position":7,"is_corresponding":false},{"id":361961,"name":"Martha E. Hensel","orcid":"0000-0001-8520-0279","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T21:40:52.680475Z","pmid":"32404509","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}