{"doi":"10.1128/msphere.00074-22","title":"Computational Modeling of Macrophage Iron Sequestration during Host Defense against Aspergillus","abstract":"Invasive pulmonary aspergillosis is a major cause of death among immunosuppressed individuals despite the best available therapy. Depriving the pathogen of iron is an essential component of host defense in this infection, but the mechanisms by which the host achieves this are complex. To understand how recruited macrophages mediate iron deprivation during the infection, we developed and validated a mechanistic computational model that integrates the available information in the field. The insights provided by this approach can help in designing iron modulation therapies as anti-fungal treatments.","journal":"mSphere","year":2022,"id":280820,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":442385,"name":"Yogesh Scindia","orcid":"0000-0001-6382-6289","position":1,"is_corresponding":false},{"id":820672,"name":"Luis Sordo Vieira","orcid":"0000-0002-3608-9356","position":2,"is_corresponding":false},{"id":955660,"name":"Henrique de Assis Lopes Ribeiro","orcid":null,"position":3,"is_corresponding":false},{"id":955270,"name":"Joseph Masison","orcid":"0000-0003-2113-9282","position":4,"is_corresponding":false},{"id":707275,"name":"Ning Yang","orcid":"0000-0002-3350-4155","position":5,"is_corresponding":false},{"id":699750,"name":"Luís L. Fonseca","orcid":"0000-0002-7902-742X","position":6,"is_corresponding":false},{"id":821054,"name":"Matthew Wheeler","orcid":null,"position":7,"is_corresponding":false},{"id":820673,"name":"Adam Knapp","orcid":"0000-0002-5719-6003","position":8,"is_corresponding":false},{"id":955271,"name":"Yu Mei","orcid":"0000-0001-7378-9880","position":9,"is_corresponding":false},{"id":847786,"name":"Brian Helba","orcid":"0000-0003-2628-805X","position":10,"is_corresponding":false},{"id":314038,"name":"Carl Atkinson","orcid":"0000-0002-0067-0210","position":11,"is_corresponding":false},{"id":955272,"name":"Will Schroeder","orcid":"0000-0003-3815-9386","position":12,"is_corresponding":false},{"id":442388,"name":"Borna Mehrad","orcid":"0000-0001-5198-065X","position":13,"is_corresponding":false},{"id":332220,"name":"Reinhard Laubenbacher","orcid":"0000-0002-9143-9451","position":14,"is_corresponding":false},{"id":821053,"name":"Bandita Adhikari","orcid":null,"position":0,"is_corresponding":true}],"reference_count":132,"raw_metadata":null,"created_at":"2026-07-19T00:29:03.247347Z","pmid":"35862797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}