{"doi":"10.1128/msphere.00011-20","title":"Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10 <sup>−/−</sup> Mice","abstract":"While family history is a significant risk factor for developing inflammatory bowel disease (IBD), it is unclear whether the microbiome from parents is a transmissible influence on disease in their offspring. Furthermore, it is unknown whether IBD-associated microbes undergo genomic adaptations during multigenerational transmission and chronic colonization in their hosts. Herein, we show that a single bacterial species, Helicobacter saguini , isolated from a nonhuman primate species with familial IBD, is transmissible from parent to offspring in germfree IL-10 −/− mice and causes multigenerational IBD. Additionally, whole-genome sequence analysis of H. saguini isolated from different mouse generations identified microevolutions in environmental interaction, nutrient metabolism, and virulence factor genes that suggest that multigenerational transmission may promote adaptations related to colonization and survival in new hosts and chronic inflammatory environments. The findings from our study highlight the importance of specific bacterial species with pathogenic potential, like H. saguini , as transmissible microorganisms in the etiopathogenesis of IBD.","journal":"mSphere","year":2020,"id":114984,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297887,"name":"Zeli Shen","orcid":"0000-0002-5278-1625","position":1,"is_corresponding":false},{"id":383089,"name":"Yan Feng","orcid":"0000-0001-6890-7053","position":2,"is_corresponding":false},{"id":540536,"name":"Dylan Puglisi","orcid":null,"position":3,"is_corresponding":false},{"id":149394,"name":"Sureshkumar Muthupalani","orcid":null,"position":4,"is_corresponding":false},{"id":62835,"name":"Mark T. Whary","orcid":null,"position":5,"is_corresponding":false},{"id":62839,"name":"James G. Fox","orcid":"0000-0001-9307-6116","position":6,"is_corresponding":false},{"id":383088,"name":"Anthony Mannion","orcid":"0000-0002-6112-0546","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-18T23:13:33.226937Z","pmid":"32213619","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}